Fracture generally affects the physical, psychological, emotional, financial and social aspects of a person's life. The ever increasing incidences, disability and agony associated with it necessitate its early and effective management. Fracture healing is by the regeneration of the bony tissues. This healing process can be altered by various internal and external factors. Today, knowledge of a wide range of factors influencing fracture-healing is available in the modern medicine. In Ayurvedic literature also, a cascade of factors influencing the fracture healing has been described. But a systematic compilation of these factors with the definitive modern scientific basis is lacking. Majority of the factors described in the texts of modern system simulate with those described in Ayurveda. By a keen understanding of the influences exerted by these factors, a rational modification can be done in the fracture management strategies. In Ayurveda, consideration has been given to the factors which influence the healing viz. Prakriti, type of injury, tissues involved, associated injuries, concomitant diseases, effect of season, treatment methods etc. A thorough knowledge of all such factors along with their practical applicability is necessary for a successful management. This paper reviews Ayurvedic literature concerning the variables which can alter the healing of fractures with possible modern interpretation.