An Avocado Constituent, Persenone A, Suppresses Expression of Inducible Forms of Nitric Oxide Synthase and Cyclooxygenase in Macrophages, and Hydrogen Peroxide Generation in Mouse Skin

Kim, Oe Kyung; Murakami, Akira; Takahashi, Daisuke; Nakamura, Yoshimasa; Torikai, Koji; Kim, Ha Won; Ohigashi, Hajime

doi:10.1271/bbb.64.2504

Cited by 35 publications

(23 citation statements)

References 7 publications

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“…Although this profile is similar to that of curcumin and nobiletin, the suppressive potency of zerumbone is higher than both, based on a comparison of their inhibitory rates (Table III). 32, 33 Suppression by zerumbone of activated leukocyte‐derived oxidative stress was anticipated, because it markedly impaired generation of reactive oxygen and nitrogen species from stimulated leukocytes in culture 15. In contrast, there are no available data on the mechanistic basis for blockade of first TPA application‐triggered chemotactic events, because pretreatment with zerumbone (810 nmol 30 min before TPA) did not affect the levels of TPA‐enhanced (8.1 nmol) expression of some proinflammatory cytokine or chemokine genes, including interleukin‐1α, granulocyte‐macrophage colony‐stimulating factor, transforming growth factor‐β and 8 S ‐lipoxygenase (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…Later, Ji and Marnett28 termed each of those applications as “priming” (the first stage, illustrated by leukocyte recruitment, maturation and infiltration of inflammatory leukocytes into inflamed lesions) and “activation” (the second stage, illustrated by the production of reactive oxygen species from accumulated leukocytes). Using this model, we demonstrated that 1′‐acetoxychavicol acetate,29 auraptene,30 AL‐131 and persenone A32 are specific inhibitors of the activation stage, while both curcumin33 and nobiletin34 are dual inhibitors.…”

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confidence: 99%

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Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice

Murakami

Tanaka

Lee

et al. 2004

Intl Journal of Cancer

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152

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We recently showed that zerumbone, a sesquiterpene found in subtropical ginger, suppresses colonic tumor marker formation in rats and induces apoptosis in colon cancer cell lines. In our present study, the anti-tumor initiating and promoting activities of zerumbone in mouse skin were evaluated using a conventional 2-stage carcinogenesis model. A single topical pretreatment to mouse skin (2 mol) 24 hr before application of dimethylbenz

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice

Murakami

Tanaka

Lee

et al. 2004

Intl Journal of Cancer

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152

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“…Furthermore, the antioxidant and anti-inflammatory capacities of avocado are well established, suggesting that incorporation of avocado into the diet might ameliorate the pathogenesis of metabolic syndrome (Kim et al, 2000a). Persenone A, a compound isolated from the avocado fruit, nearly wholly suppressed protein expression of iNOS and COX-2 in RAW 264.6 mouse macrophage cells (Kim et al, 2000b). Overall, the results from studies exploring the role of avocado in various models can be well correlated with preventive effects of avocado to obesity and diabetes.…”

Section: Exotic Fruits and Their Biodefensive Potential In Metabolmentioning

confidence: 99%

Exotic fruits as therapeutic complements for diabetes, obesity and metabolic syndrome

Devalaraja

Jain

2011

Food Research International

148

113

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The prevalence and severity of obesity, type 2-diabetes, and the resultant metabolic syndrome are rapidly increasing. As successful preventive and therapeutic strategies for these life-threatening health ailments often come with adverse side effects, nutritional elements are widely used in many countries as preventive therapies to prevent or manage metabolic syndrome. Fruits are important dietary components, and contain various bioactive constituents. Many of these constituents have been proven to be useful to manage and treat various chronic diseases such as diabetes, obesity, cancer and cardiovascular diseases. Although exotic fruits are understudied throughout the world due to their limited regional presence, many studies reveal their potent ability to ameliorate metabolic derangements and the resultant conditions i.e. diabetes and obesity. The aim of this article is to review the role of exotic fruits and their constituents in the regulation of metabolic functions, which can beneficially alter diabetes and obesity pathophysiology.

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“…Several studies on the avocado leaf extracts have shown that they possess several useful pharmacological activities, including analgesic [3], anti-inflammatory [3], hypoglycemic/hypocholesterolemic [4], hypotensive [5], anticonvulsant [6], and anti-Helicobacter pylori [7] properties. The fruit extracts have also been evaluated for and found to possess wound healing [8], chemo-preventive [9], antifungal [10], and antioxidant [11,12] properties. Avocado seed extracts have also been shown to have hypoglycemic [13] and antifungal [14] properties.…”

Section: Persea Americana: Nutritional and Medicinal Valuesmentioning

confidence: 99%

In vitro Evaluation of Genotoxicity of Avocado (Persea americana) Fruit and Leaf Extracts in Human Peripheral Lymphocytes

Kulkarni

Paul

Ganesh

2010

Journal of Environmental Science and Health, Part C

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Persea americana is much sought after both for the nutritional value of its fruit and the medicinal values of its various plant parts. A chromosomal aberration assay was undertaken to evaluate the potential genotoxicity of crude extracts from avocado fruits and leaves. Chromosomal aberrations were observed in cultured human peripheral lymphocytes exposed to separately increasing concentrations of 50% methanolic extracts of Persea americana fruit and leaves. The groups exposed to leaf and fruit extracts, respectively, showed a concentration-dependent increase in chromosomal aberrations as compared to that in a control group. The mean percentage total aberrant metaphases at 100 mg/kg, 200 mg/kg, and 300 mg/kg concentrations of leaf extract were found respectively to be 58 ± 7.05, 72 ± 6.41, and 78 ± 5.98, which were significantly higher (p < 0.0001 each) than that in the control group (6 ± 3.39). The mean percentage total aberrant metaphases at 100 mg/kg, 200 mg/kg, and 300 mg/kg concentrations of fruit extract were found to be 18 ± 5.49, 40 ± 10.00, and 52 ± 10.20, respectively, which were significantly higher (p = 0.033, p < 0.0001, and p < 0.0001, respectively) than that for control (6 ± 3.39). Acrocentric associations and premature centromeric separation were the two most common abnormalities observed in both the exposed groups. The group exposed to leaf extracts also showed a significant number of a variety of other structural aberrations, including breaks, fragments, dicentrics, terminal deletion, minutes, and Robertsonian translocations. The group exposed to leaf extract showed higher frequency of all types of aberrations at equal concentrations as compared to the group exposed to fruit extract.

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An Avocado Constituent, Persenone A, Suppresses Expression of Inducible Forms of Nitric Oxide Synthase and Cyclooxygenase in Macrophages, and Hydrogen Peroxide Generation in Mouse Skin

Cited by 35 publications

References 7 publications

Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice

Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice

Exotic fruits as therapeutic complements for diabetes, obesity and metabolic syndrome

In vitro Evaluation of Genotoxicity of Avocado (Persea americana) Fruit and Leaf Extracts in Human Peripheral Lymphocytes

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