Abstract:Road, London S W3 6JB
S U M M A R YThe binding of chlorambucil to drug-sensitive and drug-resistant Yoshida sarcoma cells has been investigated by an autoradiographic technique. The cells were treated with the drug at various concentrations both in vitro and in vivo.Using both light and electron microscope techniques, and by counting grains on various areas of the cell, the following conclusions were reached.(1) At all drug concentrations there was general cytoplasmic and nuclear uptake by both cell lines. The… Show more
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