An autoradiographic analysis of the time of appearance of neurons in the developing chick neural retina

Kahn, Arnold J.

doi:10.1016/0012-1606(74)90256-5

Cited by 337 publications

(170 citation statements)

References 13 publications

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“…Previous studies in which the optic vesicle and cup, but not the brain or optic nerve, were targeted by viral infection have demonstrated that retinal progenitor cells give rise to all neuronal cell types, as well as Mueller glia, but not to astrocytes and oligodendrocytes (Turner and Cepko, 1987;Turner et al, 1990;Fekete and Cepko 1993). Furthermore, the majority of chick retinal neurons are produced by E8 (Kahn, 1974;Mishima and Fujita, 1978;Dütting et al, 1983;Morris and Cowan, 1995), whereas astrocytes and oligodendrocytes do not start migrating into the retina until E10 (Ono et al, 1998;Fu and Qui, 2001).…”

Section: Resultsmentioning

confidence: 97%

A Common Progenitor for Retinal Astrocytes and Oligodendrocytes

Rompani¹,

Cepko²

2010

J. Neurosci.

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Developing neural tissue undergoes a period of neurogenesis followed by a period of gliogenesis. The lineage relationships among glial cell types have not been defined for most areas of the nervous system. Here we use retroviruses to label clones of glial cells in the chick retina. We found that almost every clone had both astrocytes and oligodendrocytes. In addition, we discovered a novel glial cell type, with features intermediate between those of astrocytes and oligodendrocytes, which we have named the diacyte. Diacytes also share a progenitor cell with both astrocytes and oligodendrocytes.

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Section: Resultsmentioning

confidence: 97%

A Common Progenitor for Retinal Astrocytes and Oligodendrocytes

Rompani¹,

Cepko²

2010

J. Neurosci.

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“…9). Infection at E1.5 would be expected to generate all subtypes in the ratios found in the retina, because it is a time before any neurons have been generated (20). H1 cells were most abundant at 53%, with H3 at 30% and H2 at 17%.…”

Section: Hc Subtype Within Clones Can Be Assayed Through Morphologymentioning

confidence: 99%

Retinal progenitor cells can produce restricted subsets of horizontal cells

Rompani

Cepko

2008

Proc. Natl. Acad. Sci. U.S.A.

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“…the Müller cell (reviewed by Livesey and Cepko, 2001). The proliferation and differentiation of progenitor cells are precisely regulated, and those cells located in the peripheral region of the neural retina proliferate for a longer period than the ones in the central region, which has long been known from classical autoradiography studies [in fish (Johns, 1977), in frog (Hollyfield, 1968;Jacobson, 1968), in chicken (Kahn, 1974) in mouse (Sidman, 1961)]. In the chicken neural retina, the marginal progenitor cells incorporate BrdU even after hatching, but they can differentiate into only limited neuronal cell types such as bipolar or amacrine cells (Fischer and Reh, 2000).…”

Section: Introductionmentioning

confidence: 99%

Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes

Kubo

Takeichi

Nakagawa³

2005

Development

117

120

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During the development of the central nervous system, cell proliferation and differentiation are precisely regulated. In the vertebrate eye, progenitor cells located in the marginal-most region of the neural retina continue to proliferate for a much longer period compared to the ones in the central retina, thus showing stem-cell-like properties. Wnt2b is expressed in the anterior rim of the optic vesicles, and has been shown to control differentiation of the progenitor cells in the marginal retina. In this paper,we show that stable overexpression of Wnt2b in retinal explants inhibited cellular differentiation and induced continuous growth of the tissue. Notably,Wnt2b maintained the undifferentiated progenitor cells in the explants even under the conditions where Notch signaling was blocked. Wnt2b downregulated the expression of multiple proneural bHLH genes as well as Notch. In addition,expression of Cath5 under the control of an exogenous promoter suppressed the negative effect of Wnt2b on neuronal differentiation. Importantly, Wnt2b inhibited neuronal differentiation independently of cell cycle progression. We propose that Wnt2b maintains the naive state of marginal progenitor cells by attenuating the expression of both proneural and neurogenic genes, thus preventing those cells from launching out into the differentiation cascade regulated by proneural genes and Notch.

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An autoradiographic analysis of the time of appearance of neurons in the developing chick neural retina

Cited by 337 publications

References 13 publications

A Common Progenitor for Retinal Astrocytes and Oligodendrocytes

A Common Progenitor for Retinal Astrocytes and Oligodendrocytes

Retinal progenitor cells can produce restricted subsets of horizontal cells

Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes

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