An autopsy study of 1206 acute and chronic leukemias (1958 to 1982)

Barcos, Maurice; Lane, Warren W.; Gómez, Germán A.; Han, Tao; Freeman, Arnold I.; Preisler, Harvey D.; Henderson, Edward S.

doi:10.1002/1097-0142(19870815)60:4<827::aid-cncr2820600419>3.0.co;2-a

Cited by 247 publications

(143 citation statements)

References 27 publications

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“…In autopsy studies of patients with NHL, disease in the uterus was found in approximately 0.5% (17)(18)(19). The uterus is affected more commonly by chronic lymphocytic leukemia: 7.1 to 14.0% of patients have had uterine involvement (18,20). Because of its infrequent nature, NHL involving the uterus may present diagnostic difficulties for pathologists who are unfamiliar with the clinicopathologic characteristics of the disease in this location.…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases

et al. 2000

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Non-Hodgkin's lymphomas (NHL) involving the uterus may be either low-stage neoplasms that probably arise in the uterus (primary) or systemic neoplasms with secondary involvement. In this study, 26 NHL involving the uterus are reported. Ten cases were stage I E or II E and are presumed to be primary. The mean age of patients at presentation was 55 years (range, 35 to 67 years), and abnormal uterine bleeding was the most frequent complaint (six patients). Nine of 10 tumors involved the cervix. Histologically, eight were diffuse large B-cell lymphoma (DLBCL); one was follicle center lymphoma, follicular, grade 1; and one was marginal zone B-cell lymphoma. At 5 years of clinical followup, five of six patients were alive after treatment. In 12 cases, uterine involvement was part of a systemic disease at diagnosis, either stage III E or IV. The mean patient age at the time that uterine involvement was detected was 58 years (range, 22 to 75 years); 6 of 12 had abnormal uterine bleeding. Six tumors involved both cervix and corpus, four corpus, and two cervix. Six were DLBCL; two were small lymphocytic lymphoma; three were follicle center lymphoma, follicular, grade 1 (two cases) or grade 2 (one case); and one was precursor T-cell lymphoblastic lymphoma. At 5 years of clinical follow-up, two of seven patients were alive after treatment. Four DLBCL arose in patients with incomplete clinical information; therefore, stage is unknown. We conclude that low-stage (presumably primary) uterine NHL are most commonly DLBCL, predominantly arise in the cervix, and cause abnormal uterine bleeding. High-stage NHL are a heterogeneous group of B-cell neoplasms that can involve the cervix or the corpus.

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Section: Discussionmentioning

confidence: 99%

Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases

et al. 2000

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“…The extra medullary relapse could be due to poor penetration of chemotherapy at anatomic sites of leukemic proliferation [9].…”

Section: Discussionmentioning

confidence: 99%

Bone Relapse in T Lineage Acute Lymphoblastic Leukemia in a Child: A Case Report and Review of Literature

Meena¹

2017

Arch Med

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Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. T-cell ALL accounts for 10% to 15% of cases. Acute lymphoblastic leukemia can rarely relapse in unusual extra medullary sites like bone. Hereby, we report a case of 7-years old male child presented with left arm swelling, initially confused with bone tumor but later found to be infiltration by leukemic blasts. We reviewed all previous cases and suggest that in a patient of ALL presenting with a bone swelling during or after completion of therapy, one should suspect of bone relapse.

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“…With the exception of a large autopsy series by Barcos et al 2 showing an incidental finding of CLL infiltration of the CNS in 20% of cadavers, cases of CNS involvement in B-cell CLL have rarely been reported. The majority of established cases include leptomeningeal spread and spinal cord involvement.…”

Section: Chronic Lymphocytic Leukemia Infiltration Of the Pituitary Gmentioning

confidence: 99%

“…In 2001, Rye et al 25 reported postmortem histological findings of CLL infiltration of the pituitary gland extending into the posterior pituitary stalk in a 61-year-old man with known CLL who died of complications of hyponatremia and lower respiratory tract infection. According to Barcos et al, 2 CLL infiltration of the pituitary gland associated with apoplexy had not been reported previously, although Kingdon et al 15 described a case of pituitary apoplexy in a patient with a pituitary abscess secondary to hypogammaglobulinemia from known CLL. The histopathology revealed squamous tissue and inflammatory changes consistent with an abscess with no evidence of direct CLL involvement.…”

Section: Chronic Lymphocytic Leukemia Infiltration Of the Pituitary Gmentioning

confidence: 99%

Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy

Krisht

Palmer

Couldwell

2013

JNS

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Pituitary involvement in B-cell CLL and pituitary apoplexy, independently, are 2 rare events. Their co-occurrence in addition to the presence of prolactin-secreting adenoma cells, however, has never been described in the literature. We present the case of a combined pituitary CLL and prolactinoma apoplexy in a 77-year-old man to highlight the importance of imaging the brain in patients with CLL who present with signs and symptoms of pituitary apoplexy. To the best of our knowledge, there are only 2 other reported cases of CLL manifesting as a pituitary mass lesion.11,21 The current case is the first instance of a combined pituitary CLL-prolactinoma presenting with pituitary apoplexy. This case illustrates the need to carefully evaluate pituitary tumor specimens from patients with CLL for small lymphocytic infiltration, notwithstanding the presence of pituitary adenoma cells. Case ReportHistory and Examination. This 77-year-old man with untreated CLL diagnosed 8 years earlier presented with a 2-day history of severe bifrontal headaches associated with nausea and vomiting, including left facial numbness and complete ophthalmoplegia of his left eye. Three weeks prior to his admission he was hospitalized at an outside hospital for a pulmonary embolus and discharged on a regimen of 5 mg of oral warfarin at bedtime along with subcutaneous injections of 115 mg of enoxaparin every 12 hours as a bridging therapy. At his initial examination at our institution, he was awake, alert, and fully oriented. Positive findings included complete dense ophthalmoplegia of the left eye, diminished facial sensation to all sensory modalities along the V1 and V2 distributions, and right eye blindness secondary to glaucoma. Visual acuity remained Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy The authors describe a rare case of combined pituitary chronic lymphocytic leukemia (CLL) and prolactinoma in a 77-year-old man presenting with apoplexy. This case highlights the importance of evaluating the pituitary gland in patients with CLL who present with clinical manifestations of apoplexy as well as the need to carefully evaluate pathological specimens from the gland for the presence of lymphocytic cells in those patients. This is the first reported case of a combined CLL-prolactinoma pituitary lesion presenting with apoplexy.

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An autopsy study of 1206 acute and chronic leukemias (1958 to 1982)

Cited by 247 publications

References 27 publications

Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases

Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases

Bone Relapse in T Lineage Acute Lymphoblastic Leukemia in a Child: A Case Report and Review of Literature

Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy

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