An Autopsy Case of Pulmonary Tumor Thrombotic Microangiopathy Due to Rapidly Progressing Colon Cancer in a Patient with Type 2 Diabetes

Abstract

We herein describe a case of pulmonary tumor thrombotic microangiopathy (PTTM) with rapidly progressing colon cancer. A 61-year-old man who had been receiving treatment for type 2 diabetes mellitus for 3 years was hospitalized due to critical hypoxemia. Computed tomography, which had not shown any abnormalities 3 months previously, revealed a tumor in the ascending colon, multiple nodules in the liver, and the absence of any lung abnormalities. On day 3 of hospitalization, a sudden onset of severe dyspnea and tachycardia occurred, followed by death. Autopsy revealed microscopic metastatic tumor emboli in multiple pulmonary vessels with fibrin thrombus and intimal proliferation, which led to a diagnosis of PTTM.

The relationship between the visceral adiposity index and carotid atherosclerosis in different genders and age groups

“…Herein, we found a signi cant association between VAI and CAS in different genders and age groups, which, to our knowledge, is the rst report of this association in the literature.Results of the present study showed that the carotid atherosclerosis risk in women with high VAI levels was higher than that of low-level people;Through strati ed analysis by age, this trend was found to be very signi cant in women aged 44, but this trend was not observed in women aged ≤ 44. In contrast, we found no such association in males.The present study revealed a sex and ages specifc association between visceral adiposity and CAS.The speci c reason for this difference remains unclear, and it may be related to the different distribution of sex hormones and visceral fat between men and women [34,35,36] .The average age of post-menopause in China ranged between 48 and 51 years old [37,38] . Therefore, women aged > 44 years old in the present study could be considered as part of the perimenopause population.…”

Pulmonary tumor thrombotic microangiopathy: Two case reports and literature review

“…The search identified 48 eligible clinical articles with 59 cases of PTTM reported nationally and internationally, the remaining 14 articles were excluded due to recurrence or as they were review articles. Among them, 9 Chinese PTTM articles [13–21] were reported 16 cases; 39 English PTTM articles [1,22–59] were reported 43 cases.…”