An autopsy case of primary nodal plasmacytoma associated with Sjögren’s syndrome

Watanabe, Kazuko; Yatabe, Yasushi; Narita, Masahiko; Ogawa, Takumi; Mori, Naoyoshi

doi:10.1046/j.1440-1827.1999.00896.x

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…The evolution of EMP in human patients with primary Sjögren's syndrome has been reported 23,24 . In dogs, mucocutaneous EMP often arises at or near areas of chronic immune stimulation 25 .…”

Section: Discussionmentioning

confidence: 99%

“…The evolution of EMP in human patients with primary Sjögren's syndrome has been reported. 23,24 In dogs, mucocutaneous EMP often arises at or near areas of chronic immune stimulation. 25 These data suggest the existence of pathogenetic mechanisms responsible for extramedullary B-cell differentiation and/or proliferation in patients with chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Extramedullary plasmacytoma of the third eyelid gland in a dog

Perlmann

Dagli

Martins

et al. 2009

Veterinary Ophthalmology

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A case of extramedullary plasmacytoma of the third eyelid gland in a 7-year-old American Cocker Spaniel is reported. An enlargement of the third eyelid gland, abundant mucopurulent discharge, mild hyperemia and corneal pigmentation in the OD was present. Excisional biopsy of the mass revealed the gland was infiltrated and partially destroyed by a uniform population of neoplastic plasma cells. The neoplastic cells were positive for CD138, Ki-67 and lambda light chain. CD20, CD3, kappa light chain and cytokeratin were negative. Twelve months following surgery, no recurrence was observed. To the authors' knowledge, this is the first extramedullary plasmacytoma of the third eyelid gland reported in dogs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extramedullary plasmacytoma of the third eyelid gland in a dog

Perlmann

Dagli

Martins

et al. 2009

Veterinary Ophthalmology

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“…In our cohort of patients with SS and lymphoma, MZL was also present in 83% (106/128 patients). However, development of PLNP in patients with SS is extremely rare [4, 20]. The fact that our patient had SS prompted us to critically evaluate the morphological characteristics of her lymph nodes to eliminate nodal MZL with extensive plasmacytic differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…Generalized lymph node involvement is observed rarely. Approximately 80 cases of PLNP are described in the literature, either as sporadic cases or as a small series [2–20]. …”

Section: Introductionmentioning

confidence: 99%

Unusual course of generalized lymph node primary plasmacytoma in a patient with Sjögren’s syndrome: a case report

2017

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BackgroundPrimary lymph node plasmacytoma is a rare disease that typically involves lymph nodes of the neck. In only 15% of cases is the disease generalized. Here, we present a case of generalized lymph node plasmacytoma in a patient with Sjögren’s syndrome with an unusual course.Case presentationA 48-year-old white woman presented to our hospital with enlargement of groups of lymph nodes, liver, and spleen. Her medical history was consistent with a 12-year course of Sjögren’s syndrome. Blood and urine immunochemistry showed a massive (72 g/l) M-gradient formed from immunoglobulin Aκ in the serum and monoclonal free κ-type light chains in her urine. A skeletal X-ray revealed no bone destruction. Cytological and histological bone marrow assays showed no signs of plasma cell infiltration. The microarchitecture of her neck and inguinal lymph nodes was destroyed. Only small remnants of B cell follicles were found, while the interfollicular areas were expanded and infiltrated by CD138, MuM1, CD43, and IgAκ-positive plasma cells. After nine cycles of doxorubicin, cyclophosphamide, vincristine, and prednisolone chemotherapy, complete remission was achieved. However, the lymphoma relapsed 3 months later, with histological verification in her femoral lymph node. Despite the absence of subsequent adequate therapy, she gradually achieved complete remission of plasmacytoma with the disappearance of paraproteins.ConclusionsCurrently, primary lymph node plasmacytoma is generally considered a nodal marginal zone lymphoma with an extensive plasmacytic differentiation. In our case, despite the critical histological and immunohistochemical evaluation of three lymph node biopsies from different anatomical areas at different times, no signs of nodal marginal zone lymphoma were found. An 18-year follow-up of our patient with primary lymph node plasmacytoma demonstrated an extremely unusual clinical course. Initially, primary lymph node plasmacytoma was refractory to chemotherapy. However, subsequently, she underwent a complete spontaneous remission of plasmacytoma.

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“…One case of primary nodal plasmacytoma with Sjögren's syndrome has been described but without amyloidosis 14. Wong et al reported on a patient with secondary amyloidosis (amyloid protein AA) of the lung during Sjögren's syndrome 15…”

Section: Discussionmentioning

confidence: 99%

Concomitant diagnosis of primary Sjogren's syndrome and systemic AL amyloidosis

Delévaux

2001

Annals of the Rheumatic Diseases

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A 48 year old woman was referred to hospital for buccal discomfort. Physical examination showed a macroglossia and features of xerostomia. She was diagnosed as having primary Sjögren's syndrome according to the criteria proposed by the European Community study group in 1993. Furthermore, a lower lip salivary gland biopsy showed amyloid deposits that were also seen in the stomach and in the bone marrow. Echocardiography was consistent with cardiac amyloidosis. Serum immunofixation identified a monoclonal IgG . As far as is known, this is the first report of systemic primary amyloidosis associated with Sjögren's syndrome. The relation between these two disorders is discussed.

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An autopsy case of primary nodal plasmacytoma associated with Sjögren’s syndrome

Cited by 5 publications

References 13 publications

Extramedullary plasmacytoma of the third eyelid gland in a dog

Extramedullary plasmacytoma of the third eyelid gland in a dog

Unusual course of generalized lymph node primary plasmacytoma in a patient with Sjögren’s syndrome: a case report

Concomitant diagnosis of primary Sjogren's syndrome and systemic AL amyloidosis

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