Forty-five "at risk" pregnancies were serially monitored by sonar biparietal cephalometry, 24-hour urinary oestriol assays and determination of serum oxytocinase, total alkaline phosphatase and heat-stable alkaline phosphatase activities. The results were assessed by a scoring system, and it was found that a combination of sonar cephalometry and 24-hour urinary oestriol assays gave the most reliable prediction of intrauterine growth retardation.