An autoimmune-mediated strategy for prophylactic breast cancer vaccination

Jaini, Ritika; Kesaraju, Pavani; Johnson, Justin M.; Altuntas, Cengiz Z.; Jane‐wit, Dan; Tuohy, Vincent K.

doi:10.1038/nm.2161

Cited by 97 publications

(81 citation statements)

References 25 publications

(27 reference statements)

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“…Because alpha-lactalbumin is conditionally expressed only during lactation, vaccination-induced prophylaxis occurs without any detectable inflammation in normal nonlactating breast tissue. Thus, alpha-lactalbumin vaccination may provide safe and effective protection against the development of breast cancer for women in their post-childbearing, premenopausal years, during which lactation is readily avoidable and the risk for developing breast cancer is high (Jaini et al, 2010).…”

Section: Breast Milkmentioning

confidence: 99%

Breastfeeding and its Relationship with Reduction of Breast Cancer: A Review

França-Botelho¹,

Ferreira²,

França³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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In this review, we describe the patterns of known immunological components in breast milk and examine the relationship between breastfeeding and reduced risk of breast cancer. The top risk factors for breast cancer are a woman's age and family history, specifically having a first-degree relative with breast cancer. Women that have a history of breastfeeding have been shown to have reduced rates of breast cancer. Although the specific cause has not been elucidated, previous studies have suggested that breastfeeding reduces the risk of breast cancer primarily through two mechanisms: the differentiation of breast tissue and reduction in the lifetime number of ovulatory cycles. In this context, one of the primary components of human milk that is postulated to affect cancer risk is alpha-lactalbumin. Tumour cell death can be induced by HAMLET (a human milk complex of alpha-lactalbumin and oleic acid). HAMLET induces apoptosis only in tumour cells, while normal differentiated cells are resistant to its effects. Therefore, HAMLET may provide safe and effective protection against the development of breast cancer. Mothers should be encouraged to breastfeed their babies because the complex components of human milk secretion make it an ideal food source for babies and clinical evidence has shown that there is a lower risk of breast cancer in women who breastfed their babies.

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Section: Breast Milkmentioning

confidence: 99%

Breastfeeding and its Relationship with Reduction of Breast Cancer: A Review

França-Botelho¹,

Ferreira²,

França³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Analogous to a cancer cell with aberrant protein expression, an HIV-1-infected cell will express APOBEC3-derived peptide epitopes at a higher frequency than uninfected cells. In the cancer field, many studies have approached cancer immunotherapy with self-antigens expressed in tumors (32,33). In addition, the cancer therapeutic vaccination field has used self-antigens (e.g., melanomaassociated antigen [MAGE] peptides for melanoma) with good safety profiles and successful induction of immune responses (34).…”

Section: Discussionmentioning

confidence: 99%

T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques

Champiat

Garrison

Raposo

et al. 2013

J Virol

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APOBEC3 proteins mediate potent antiretroviral activity by hypermutating the retroviral genome during reverse transcription. To counteract APOBEC3 and gain a replicative advantage, lentiviruses such as human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have evolved the Vif protein, which targets APOBEC3 proteins for proteasomal degradation. However, the proteasome plays a critical role in the generation of T cell peptide epitopes. Whether Vif-mediated destruction of APOBEC3 proteins leads to the generation and presentation of APOBEC3-derived T cell epitopes on the surfaces of lentivirus-infected cells remains unknown. Here, using peptides derived from multiple Vif-sensitive APOBEC3 proteins, we identified APOBEC3-specific T cell responses in both HIV-1-infected patients and SIV-infected rhesus macaques. These results raise the possibility that these T cell responses may be part of the larger antiretroviral immune response.

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“…Furthermore, its expression in normal tissue should be conditional, and the condition determining expression of the target antigen in normal tissue should be readily avoidable [54].…”

Section: Self-targets For Prophylactic Breast Cancer Vaccinationmentioning

confidence: 99%

Potential Use of Vaccines in the Primary Prevention of Breast Cancer in High-Risk Patients

Lazzeroni

Serrano²

2012

Breast Care

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Cancer vaccines are an emerging therapeutic and prophylactic modality that may play a more important role in cancer prevention and treatment in the future. Therapeutic cancer vaccines are designed to generate a targeted, immune-mediated antitumor response. Successful prophylactic vaccines are those against oncogenic viral infections, such as the human papillomavirus and cervical cancer. However, a tough challenge for the majority of tumor vaccines is the self-nature of tumor antigens. Ongoing studies are investigating methods to enhance vaccine strategies including immune-modulating agents. The present review analyzes the potential use of vaccines in the primary prevention of breast cancer, focusing on the recent extension of vaccine target selection to self-proteins that are overexpressed during the early stages of tumor development but whose expression no longer occurs as we age, a feature that may avoid clinically significant autoimmune sequelae.

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An autoimmune-mediated strategy for prophylactic breast cancer vaccination

Cited by 97 publications

References 25 publications

Breastfeeding and its Relationship with Reduction of Breast Cancer: A Review

Breastfeeding and its Relationship with Reduction of Breast Cancer: A Review

T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques

Potential Use of Vaccines in the Primary Prevention of Breast Cancer in High-Risk Patients

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