An autoimmune aetiology for hypothyroidism following interferon therapy for breast cancer

Thyroiditis after treatment with interleukin-2 and interferon α-2a

“…Functional NK and LAK activity of PNMCs and the number of PMNCs with NK markers were determined at baseline and after stimulation at day 8 of the third and three of 13 (23%) patients treated for breast cancer (Fentimann et al, 1988). The thyroid dysfunction observed in our study is caused by an autoimmune thyroiditis, as evidenced by the evolution of thyroid function studies, the cellular infiltrates in fine-needle aspirates and by the expression of HLA class II antigens by thyroid epithelial cells.…”

Thyroiditis after treatment with interleukin-2 and interferon α-2a

“…Functional NK and LAK activity of PNMCs and the number of PMNCs with NK markers were determined at baseline and after stimulation at day 8 of the third and three of 13 (23%) patients treated for breast cancer (Fentimann et al, 1988). The thyroid dysfunction observed in our study is caused by an autoimmune thyroiditis, as evidenced by the evolution of thyroid function studies, the cellular infiltrates in fine-needle aspirates and by the expression of HLA class II antigens by thyroid epithelial cells.…”

Incidence of Dysthyroidism during Interferon Therapy in Chronic Hepatitis C

“…The variability of the disease is extreme, as noted in previous series [1][2][3][4][5][6][7][8][9][10][11][12]: hyper-or hypothyroidism, 'biphasic' patterns with transient hyperthyroidism followed by hypothyroidism, associated or not with TPO Ab orTg Ab. In our series, the delay between the initiation of IFN ther apy and the onset of the thyroid disease varied widely, from 4 to 13 months.…”

Suppression of HLA class II expression on thyrocytes by interferon-alpha 1

“…In this latter study, antigen presenting ability was simultaneously enhanced. However, this does not necessarily follow, as shown by the studies of Rhodes et al (1986) IFN-a (Burman et al, 1986;Fentiman et al, 1988;Gisslinger, Gilly & Weissel, 1989). Such preparations may possibly contain low levels of other cytokines, including IFN-y.…”

Thyroiditis after treatment with interleukin-2 and interferon α-2a

“…Functional NK and LAK activity of PNMCs and the number of PMNCs with NK markers were determined at baseline and after stimulation at day 8 of the third and three of 13 (23%) patients treated for breast cancer (Fentimann et al, 1988). The thyroid dysfunction observed in our study is caused by an autoimmune thyroiditis, as evidenced by the evolution of thyroid function studies, the cellular infiltrates in fine-needle aspirates and by the expression of HLA class II antigens by thyroid epithelial cells.…”

Incidence of Dysthyroidism during Interferon Therapy in Chronic Hepatitis C

“…The variability of the disease is extreme, as noted in previous series [1][2][3][4][5][6][7][8][9][10][11][12]: hyper-or hypothyroidism, 'biphasic' patterns with transient hyperthyroidism followed by hypothyroidism, associated or not with TPO Ab orTg Ab. In our series, the delay between the initiation of IFN ther apy and the onset of the thyroid disease varied widely, from 4 to 13 months.…”

Suppression of HLA class II expression on thyrocytes by interferon-alpha 1

“…In this latter study, antigen presenting ability was simultaneously enhanced. However, this does not necessarily follow, as shown by the studies of Rhodes et al (1986) IFN-a (Burman et al, 1986;Fentiman et al, 1988;Gisslinger, Gilly & Weissel, 1989). Such preparations may possibly contain low levels of other cytokines, including IFN-y.…”

Thyroiditis after treatment with interleukin-2 and interferon α-2a

“…Functional NK and LAK activity of PNMCs and the number of PMNCs with NK markers were determined at baseline and after stimulation at day 8 of the third and three of 13 (23%) patients treated for breast cancer (Fentimann et al, 1988). The thyroid dysfunction observed in our study is caused by an autoimmune thyroiditis, as evidenced by the evolution of thyroid function studies, the cellular infiltrates in fine-needle aspirates and by the expression of HLA class II antigens by thyroid epithelial cells.…”

Incidence of Dysthyroidism during Interferon Therapy in Chronic Hepatitis C

“…The variability of the disease is extreme, as noted in previous series [1][2][3][4][5][6][7][8][9][10][11][12]: hyper-or hypothyroidism, 'biphasic' patterns with transient hyperthyroidism followed by hypothyroidism, associated or not with TPO Ab orTg Ab. In our series, the delay between the initiation of IFN ther apy and the onset of the thyroid disease varied widely, from 4 to 13 months.…”

Suppression of HLA class II expression on thyrocytes by interferon-alpha 1

“…In this latter study, antigen presenting ability was simultaneously enhanced. However, this does not necessarily follow, as shown by the studies of Rhodes et al (1986) IFN-a (Burman et al, 1986;Fentiman et al, 1988;Gisslinger, Gilly & Weissel, 1989). Such preparations may possibly contain low levels of other cytokines, including IFN-y.…”