An audit of over 1000 breast cancer patients from a tertiary care center of Northern India

Abstract

Background: Breast cancer is the commonest cancer among women. India along with United States and China collectively account for one third of the global burden. The present study reports the clinico-epidemiological data of our patient population. This may help in better understanding of the disease in our population and also form ground for conducting further breast cancer research in India. Methods: The study was conducted at an apex teaching and medical research institution in India from September 2013 to April 2015 as a retrospective review of prospectively collected data of breast cancer patients. The socio-demographic characteristics, reproductive risk factors, clinical presentation, TNM staging and histopathological characteristics for breast cancer in these patients were recorded. The data was recorded on an Xcel spreadsheet and analyzed using IBM SPSS 21. Results:The study comprised of 1310 breast cancer patients with males comprising 1.1%. The median age of presentation was 47 years, and menarche 14 years. Most of women were married and multiparous. More than half of the women were postmenopausal at presentation. All patients were symptomatic at presentation with median duration of symptom of 5 months and median lump size of 5 cm. Most common stage at presentation was Stage II and most common histopathology was Invasive ductal carcinoma. 61.9% tumors were hormone receptor positive. Triple negative cancers formed one third of all tumors. Conclusion: Breast cancer in the Indian scenario is a disease of younger woman who lack the characteristic reproductive and demographic risk factors. This calls for a need to study the clinico-demographic risk factors and characteristics of our own population.

Assess the Prevalence for Needs of Breast Cancer Survivors' in the Oncology Ward at a Selected Tertiary Care Hospital

“…According to Neelam Sharma's findings, 75% of the respondents had a low socioeconomic status study findings corresponds to present study [16]. According to Suhani S. et al (2020), 50 % of post -menopausal women 39 (32.5%) of those who participated were over the age of 45 current findings corresponds with the study [17].…”

“…Present study found 81.66% women were married findings were congruent with Nitin Gangane et al A 2017 study the majority of participants, or 83.6%, were married [15]. Current study found that 90% of participants had no family history of breast cancer, similar findings were reported by Suhani S. et al (2020)15% of the participants had a family history of BC [17]. B et al 2016 reported that approximately 89 percent of participants had mastectomy and surgical treatment, which corresponds with the current study [18].…”

Germline variants profiling of BRCA1 and BRCA2 in Chinese Hakka breast and ovarian cancer patients

“…Of course, there are some populations with higher rates of breast cancer in men. For example, the male breast rate is 1.1% in Northern India [ 75 ], and it is higher in some populations in Africa (6.2% in North Uganda [ 76 ], 2.6% in Burkina Faso [ 77 ], and 3.2% in 27 African countries [ 78 ]). Epidemiological differences between different groups of people may be related to region, race and living environment.…”

Community Hospital Multidisciplinary Breast Conference Data Analysis - A Pathologist’s Perspective

“…The median incidence of invasive lobular carcinoma is about 11% in Western countries [40]. These tumors are predominantly ER-and PRpositive and Her2-negative [41][42][43][44][45][46] and the majority of Her2positive lobular carcinomas are pleomorphic variants [44,45]. We report a 12.7% rate of lobular carcinomas.…”