An Atypical Form of Necrotizing Periodontitis

Güvenç, Dilek; Gökbuget, Aslan; Çintan, Serdar; Kara, Goze; Çifçibaşı, Emine; Ünüvar, Emin; Çıftçı, Sevgi; Külekçi, Güven; Yaltırık, Mehmet; Kılıçoğlu, Hülya

doi:10.1902/jop.2009.090146

Cited by 5 publications

(2 citation statements)

References 13 publications

(47 reference statements)

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“…18 Previous case report studies also indicated that the condition is associated with other systemic diseases, including scurvy, malnutrition, following chemotherapy, neutropenia, and agranulocytosis. [19][20][21][22] Among the various investigations, evidence shows that malnutrition is a significant risk factor for the development and pathogenesis of necrotizing periodontal diseases, especially among individuals within poor or socioeconomic countries. [23][24][25][26] This can be attributed to the significant alteration in the acute phase response against the infections (among patients suffering from protein-energy malnutrition), in addition to the significant reduction in the number of antioxidant nutrients that are responsible for fighting the infections and strengthening the host immune response.…”

Section: Discussionmentioning

confidence: 99%

Etiology and types of necrotizing periodontal diseases

Abdullah

Albeshr

Albasher

et al. 2021

Int J Community Med Public Health

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Necrotizing periodontal diseases pose a clinical significance because it has been associated with a severe prognosis that can cumulatively lead to rapid tissue destruction. A slow rate of destruction has been reported for patients with necrotizing periodontal diseases, and reports show that chronicity might be a characteristic in some patients, while many patients might also suffer from disease recurrence. The association of other oral lesions might also be a characteristic in some situations, which usually occurs in cases when systemic involvement is present. In the present literature review, we aim to discuss the etiology and types of necrotizing periodontal diseases based on evidence from the different related studies in the literature. Microbiology plays an important role in the pathogenesis of the condition, and some organisms as spirochetes were directly correlated with the etiology of the condition. Evidence also shows that the presence of the different risk factors might be the major contributor to the development of the condition as different risk factors were found to be directly correlated with the disease. Among the different factors, impacted host immune response and the presence of deteriorating systemic conditions have been widely reported in the literature as significant factors predisposing to developing the disease. Other factors as smoking and alcohol consumption, previous history of the disease, and other oral lesions, were also reported. Further research is needed for better classification of the condition and determination of more significant risk factors.

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Section: Discussionmentioning

confidence: 99%

Etiology and types of necrotizing periodontal diseases

Abdullah

Albeshr

Albasher

et al. 2021

Int J Community Med Public Health

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“…The presence of F. necrophorum in ANUG is less well documented. An atypical form of necrotizing periodontitis has been reported but F. necrophorum was not isolated [42].…”

Section: Review Dahlén and Ebenfeltmentioning

confidence: 99%

Necrobacillosis in humans

Dahlén¹,

Ebenfelt²

2011

Expert Review of Anti-infective Therapy

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Necrobacillosis, often used synonymously with Lemierre's syndrome, is a form of abscess infection in the peritonsillar area associated with a thrombophlebitis and caused by the strict anaerobic species Fusobacterium necrophorum. The thrombosis formed affects the internal jugular vein, from which the bacteria are seeded out in the bloodstream and cause bacteremia. Septicemia is a common complication with an often fatal outcome. Necrobacillosis is very rare and is referred to as the 'forgotten disease'. It is probably frequently overlooked in clinical practice in its early and milder forms such as tonsillitis (sore throat) and peritonsillar abscess. F. necrophorum frequently participates in these infections and is thus suspected to have an etiological role in Lemierre's syndrome. Similarly, F. necrophorum seems to play an important role in noma (cancrum oris) and this disease is also included in the necrobacillosis complex. Diagnosis of infections of the necrobacillosis complex seeks to disclose F. necrophorum in swab samples or blood culture. The most commonly used therapy is metronidazole in combination with penicillin or amoxicillin. Clindamycin is also an option, especially in cases of penicillin allergy.

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