An atypical extrahepatic metastasis of the distal phalanx from hepatocellular carcinoma

Abstract

A 49-year-old woman presented with severe swelling and pain of the left little finger, which had exacerbated rapidly, in October 2006. The patient had a history of hepatocellular carcinoma and metastatic lung cancer. She had undergone partial hepatectomy for the hepatocellular carcinoma in September 2001 and pulmonary resection for metastatic lung cancer in November 2005. Roentgenogram of the hand on admission showed complete destruction of the distal phalanx of the left little finger. The final pathological result of the tissue obtained by disarticulation was an extrahepatic metastasis of hepatocellular carcinoma. Extrahepatic metastasis from primary hepatocellular carcinoma to the hand is very rare and only four cases have been reported in the literature. All the patients with extrahepatic metastases from the primary hepatocellular carcinoma to the hand had poor prognoses, but the patient presented in this article exhibited an unusual clinical course. The patient is still alive 1 year after the diagnosis of extrahepatic bone metastasis of the distal phalanx.

Unusual presentation of hepatocellular carcinoma invading the anterior abdominal wall muscles

“…This is one of the rare instances of bony metastatic HCC. Munk et al demonstrated metastasis in HCC to sacrum and gluteus muscles while Matsunaga et al found extrahepatic metastasis to the distal phalanx of a finger [12] Darzi et al demonstrated abdominal wall metastasis following HCC after laparoscopy [13]. Alpha fetoprotein (AFP) usually correlates with tumor size and doubling time of AFP correlates with the tumor doubling time.…”

Metastatic Hepatocellular Carcinoma to the Distal Phalanx: a Case Report and Review of Literature

“…Especially, bone metastasis of hepatocellular carcinoma to the hand is extremely rare. To our knowledge, only five cases have been reported in the literature (7)(8)(9)(10)(11). We report the case of 60-year-old patient with metastatic hepatocellular carcinoma of the distal phalanx of the right 4…”