An Atypical Case of Pityriasis Rosea Gigantea after Influenza Vaccination

Abstract

Pityriasis rosea is a common erythematosquamous eruption, typically presenting along the cleavage lines of the skin. A wide spectrum of atypical manifestations may challenge even the most experienced physician. Here we report a rare case of a suberythrodermic pityriasis rosea with gigantic plaques after an influenza vaccination, and we discuss the possible triggers of atypical manifestations of such a common dermatological disease in the setting of an altered immunity.

Clinical variants of pityriasis rosea

“…PR has been also reported following vaccinations as well (B acillus Calmette-Guerin, influenza, H1N1, diphtheria, smallpox, hepatitis B, pneumococcus, etc . )[ 45 , 46 ].…”

Pityriasis Rosea-Like Rash as a Cutaneous Marker for COVID-19 Infection

“…[12][13][14][15] Diminished levels of natural killer (NK) cells and B-cells activity in the lesions of PR have been observed. 16 This suggests the role of a T-cell mediated immunity. Besides, increased amounts of CD4 T cells and Langerhans cells have been found in the dermis, which possibly points towards viral antigen processing and presentation.…”

A Herald Patch Almost Encircling the Trunk—Extreme Pityriasis Rosea Gigantea in a Young Child

“…PR gigantea is one of the atypical variants in the classification of PR . It has been reported in adults , but the occurrence in a young child with a herald patch nearly encircling the trunk, is an exceedingly rare presentation.…”