An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure

Abstract

Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. Here, we present the case of a woman we diagnosed with an uncharacteristic expression of myxedema coma and nonconvulsive seizure complicated by a right middle cerebral artery infarct.

Myxedema heart disease and non-comatose presentation of myxedema: A case report

“… 14 Even though MC classically presents with altered mental status, other neurological features such as abnormal movement disorders have also been scarcely reported in the literature. 15 Some animal experiments have shown the incidence of seizures in severe hypothyroidism following thyroidectomy, in addition to reduced photo-paroxysmal epileptic response in baboons. 8 Nevertheless, seizures caused by MC are not precisely understood.…”