An Atypical Case of Microcysts Associated With Silicone Hydrogel Contact Lens: Findings on In Vivo Confocal Laser Microscopy

Toshida, Hiroshi; Murakami, Akira

doi:10.1097/icl.0b013e3181998dec

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Several other protein synthesis inhibitors tested show amoebicidal properties but have limited cysticidal effects. These include prednisolone (irreversibly binds with glucocorticoid receptors, inhibiting gene transcription for cytochrome oxidase 2 , cytokines, cell adhesion molecules, and inducible NO synthase) (52), beta-methasone phosphate (binds to plasma transcortin and becomes active when it is not bound to transcortin) (81), and linezolid (inhibits the formation of subunits of ribosome) (39,41,50,51,71,72).…”

Section: Protein Synthesis-inhibiting Drugsmentioning

confidence: 99%

The Development of Drugs against Acanthamoeba Infections

Siddiqui

Aqeel

Khan

2016

Antimicrob Agents Chemother

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For the past several decades, there has been little improvement in the morbidity and mortality associated with Acanthamoeba keratitis and Acanthamoeba encephalitis, respectively. The discovery of a plethora of antiacanthamoebic compounds has not yielded effective marketed chemotherapeutics. The rate of development of novel antiacanthamoebic chemotherapies of translational value and the lack of interest of the pharmaceutical industry in developing such chemotherapies have been disappointing. On the other hand, the market for contact lenses/contact lens disinfectants is a multi-billion-dollar industry and has been successful and profitable. A better understanding of drugs, their targets, and mechanisms of action will facilitate the development of more-effective chemotherapies. Here, we review the progress toward phenotypic drug discovery, emphasizing the shortcomings of useable therapies.

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Section: Protein Synthesis-inhibiting Drugsmentioning

confidence: 99%

The Development of Drugs against Acanthamoeba Infections

Siddiqui

Aqeel

Khan

2016

Antimicrob Agents Chemother

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“…Toshida and Muakami 18 reported an atypical case of microcysts associated with silicone hydrogel contact lens wear based on observations with an in vivo confocal laser microscope. They reported that treatment with betamethasone phosphate and levofloxacin eye drops (both five times daily) resulted in alleviation of the condition after 10 days.…”

mentioning

confidence: 99%