An atypical case of eosinophilic pustular folliculitis with associated secondary follicular mucinosis treated with indomethacin

Grant, Garett J.; Sahni, Dev R; Florell, Abigail J.; Hull, Christopher M.; Florell, Scott R.; Miles, Rodney R.; Wada, David A.; Bowen, Anneli R.

doi:10.1016/j.jdcr.2022.12.022

Cited by 1 publication

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“…Still, it has been suggested that follicular damage may be due to an increase in eosinophilic leukocytes in the blood, which is nonspecifically recruited into the sebaceous follicles by chemotactic substances and mixed with neutrophils, which in turn cause fragmentation of the follicular epithelium and the formation of These cells, cause fragmentation of the follicular epithelium, resulting in small abscesses and mucinosis-like changes. 12,13 One patient in this group had follicular mucin deposits, and the clinical and laboratory tests ruled out connective tissue disease. Pruritus was a common symptom reported by patients, and eosinophilia was increased in varying degrees, but not in all patients, probably related to the onset and time of consultation, indicating that eosinophilia is not a constant feature, 14 and one study noted that eosinophilia was found in 25-86% of this group of patients.…”

Section: Discussionmentioning

confidence: 91%

Clinical and Pathological Analysis of 10 Cases of Eosinophilic Pustular Folliculitis

Li,

Chen,

Zhou

et al. 2023

CCID

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We conducted a retrospective analysis of clinical and pathologic data from January 2020 to June 2023, focusing on 10 patients diagnosed with eosinophilic pustular folliculitis at our dermatology clinic. Four of the ten patients had the first rash on the face, five on the trunk, and one on the palms and feet, all of which were initially scattered papules that gradually increased and fused into erythematous plaques with a circular distribution. Seven had pustules with small surface desquamation, and three cases had micro swelling on the face. The rash involved only the face in 5 cases, the face and trunk in 5 cases, and the face, trunk, hands, and feet in 1 case. Seven of the ten patients were pruritic, and 3 had no obvious pruritus. The histopathological features were mild epidermal hyperplasia, lymphocytic and eosinophilic infiltration around the superficial middle dermal vessels and appendages, and eosinophilic and neutrophilic abscesses in the local hair follicles. Treatment with oral indomethacin, prednisone, and minocycline was effective.

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Section: Discussionmentioning

confidence: 91%