An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications

Soricellis, Giulia De; Fagnani, Francesco; Colombo, Alessia; Dragonetti, Claudia; Roberto, Dominique; Marinotto, Daniele; Hartnell, David; Hackett, Mark J.; Massi, Massimiliano; Carboni, Bertrand; Guerchais, Véronique

doi:10.1016/j.dyepig.2022.111012

Cited by 4 publications

(4 citation statements)

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“…237 Colombo and coworkers have designed three iridium(III) complexes appended with a tryptophan moiety (105) (Chart 48) for neuroimaging. 238 These tryptophan conjugates preferentially stain neuronal cells in ex vivo thin sections of rat cerebellum tissues. Among the three complexes, complex 105c shows the highest affinity for cerebellar granule and purkinje cells, and it is mainly distributed in the cytoplasmic region after cellular uptake.…”

Section: Transition Metal−biomolecule Conjugatesmentioning

confidence: 97%

“…Tryptophan serves as a precursor for serotonin, a neurotransmitter involved in a wide range of neurological processes, and its metabolism has implications in various neurodegenerative disorders and cancer . Colombo and co-workers have designed three iridium(III) complexes appended with a tryptophan moiety ( 105 ) (Chart ) for neuroimaging . These tryptophan conjugates preferentially stain neuronal cells in ex vivo thin sections of rat cerebellum tissues.…”

Section: Luminescent Transition Metal Conjugates For Bioimagingmentioning

confidence: 99%

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Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

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Luminescence imaging is a powerful and versatile technique for investigating cell physiology and pathology in living systems, making significant contributions to life science research and clinical diagnosis. In recent years, luminescent transition metal complexes have gained significant attention for diagnostic and therapeutic applications due to their unique photophysical and photochemical properties. In this Review, we provide a comprehensive overview of the recent development of luminescent transition metal complexes for bioimaging and biosensing applications, with a focus on transition metal centers with a d 6 , d 8 , and d 10 electronic configuration. We elucidate the structure−property relationships of luminescent transition metal complexes, exploring how their structural characteristics can be manipulated to control their biological behavior such as cellular uptake, localization, biocompatibility, pharmacokinetics, and biodistribution. Furthermore, we introduce the various design strategies that leverage the interesting photophysical properties of luminescent transition metal complexes for a wide variety of biological applications, including autofluorescence-free imaging, multimodal imaging, organelle imaging, biological sensing, microenvironment monitoring, bioorthogonal labeling, bacterial imaging, and cell viability assessment. Finally, we provide insights into the challenges and perspectives of luminescent transition metal complexes for bioimaging and biosensing applications, as well as their use in disease diagnosis and treatment evaluation.

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Section: Transition Metal−biomolecule Conjugatesmentioning

confidence: 97%

Section: Luminescent Transition Metal Conjugates For Bioimagingmentioning

confidence: 99%

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

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“…Iridium complexes are well known for their outstanding tuneable luminescence properties, that allow their application in electroluminescence devices 1 and as bioimaging sensors, 2,3 and for their intriguing second-order nonlinear optical (NLO) properties. 4,5 Iridium complexes have attracted attention also for their two-photon absorption (TPA) activity.…”

Section: Introductionmentioning

confidence: 99%

Two-photon absorption properties of simple neutral Ir(iii) complexes

Garoni,

Colombo,

Roberto

et al. 2024

Phys. Chem. Chem. Phys.

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“…Iridium complexes, compared to other transition metal complexes, exhibit excellent photochemical and physical stability, large Stokes shift, and high intersystem crossover ability [14]. Consequently, they have emerged as extensively utilized transition metal complex materials across various domains such as bioimaging, electroluminescence, and photodynamic therapy [15][16][17][18][19]. Notably, iridium complexes have been extensively investigated as photosensitizers in photodynamic therapy [20,21].…”

Section: Introductionmentioning

confidence: 99%

An AIE Metal Iridium Complex: Photophysical Properties and Singlet Oxygen Generation Capacity

Zhu,

Liu,

Wang

et al. 2023

Molecules

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Photodynamic therapy (PDT) has garnered significant attention in the fields of cancer treatment and drug-resistant bacteria eradication due to its non-invasive nature and spatiotemporal controllability. Iridium complexes have captivated researchers owing to their tunable structure, exceptional optical properties, and substantial Stokes displacement. However, most of these complexes suffer from aggregation-induced quenching, leading to diminished luminous efficiency. In contrast to conventional photosensitizers, photosensitizers exhibiting aggregation-induced luminescence (AIE) properties retain the ability to generate a large number of reactive oxygen species when aggregated. To overcome these limitations, we designed and synthesized a novel iridium complex named Ir-TPA in this study. It incorporates quinoline triphenylamine cyclomethylated ligands that confer AIE characteristics for Ir-TPA. We systematically investigated the photophysical properties, AIE behavior, spectral features, and reactive oxygen generation capacity of Ir-TPA. The results demonstrate that Ir-TPA exhibits excellent optical properties with pronounced AIE phenomenon and robust capability for producing singlet oxygen species. This work not only introduces a new class of metal iridium complex photosensitizer with AIE attributes but also holds promise for achieving remarkable photodynamic therapeutic effects in future cellular experiments and biological studies.

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An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications

Cited by 4 publications

References 67 publications

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Two-photon absorption properties of simple neutral Ir(iii) complexes

An AIE Metal Iridium Complex: Photophysical Properties and Singlet Oxygen Generation Capacity

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