An ATP/ATPase responsive supramolecular fluorescent hydrogel constructed<i>via</i>electrostatic interactions between poly(sodium<i>p</i>-styrenesulfonate) and a tetraphenylethene derivative

Hu, Wang; Ji, Xiaofan; Li, Yang; Li, Zhengtao; Tang, Guping; Huang, Feihe

doi:10.1039/c8tb00366a

Cited by 61 publications

(37 citation statements)

References 71 publications

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“… 31 , 32 Recently, a novel supramolecular fluorescent hydrogel with ATP/ATPase responsiveness was synthesized through the electrostatic interaction between poly(sodium p -styrene sulfonate) and tetraphenylethene derivatives with two quaternary ammonium cations. 33 These assemblies found applications in tissue engineering, 34 drug delivery, 35 optical field, 36 as injectable gels, 37 , 38 cell scaffolds, 39 − 41 self-healing materials, 42 − 44 and biosensors 45 to cite a few.…”

Section: Introductionmentioning

confidence: 99%

Thermo-Switchable de Novo Ionic Liquid-Based Gelators with Dye-Absorbing and Drug-Encapsulating Characteristics

et al. 2018

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An ionic liquid-based surfactant with ester functionality self-aggregates in an aqueous medium and forms ionogels at 8.80% (w/v) concentration at physiological pH. The ionogel exhibited a remarkable change in its appearance with temperature from fibrillar opaque to transparent because of the dynamic changes within its supramolecular structure. This gel-to-gel phase transition occurs below the melting point of the solid ionic liquid. The ionogels were investigated using turbidity, differential scanning calorimetry, scanning electron microscopy (SEM), field emission SEM (FE-SEM), inverted microscopy, transmission electron microscopy imaging, Fourier transform infrared spectroscopy, and rheological measurements. The fibrillar opaque ionogel and transparent ionogel were studied for their ability to absorb dyes (methyl orange and crystal violet) and to encapsulate drugs (diclofenac sodium and imatinib mesylate).

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Section: Introductionmentioning

confidence: 99%

Thermo-Switchable de Novo Ionic Liquid-Based Gelators with Dye-Absorbing and Drug-Encapsulating Characteristics

et al. 2018

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“…The gel to sol transformation clearly observed upon addition of ATP (adenosine triphosphate) whereas the phosphatase ATPase leads sol to gel transition. The development of supramolecular hydrogels significant in bioimaging …”

Section: Utilization Of External Stimuli Sourcesmentioning

confidence: 99%

Recent Advances on Stimuli‐Responsive Smart Materials and their Applications

2019

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Stimuli‐responsive materials have raised major attention in digital technology, sensors and biomedical applications owing to quick response towards external stimuli, for example light, voltage, pressure, temperature, mechanical friction and pH. Nevertheless, action of external stimuli on organic materials affects their internal physico‐chemical properties and facilitates improved thermal/photo stability, tuning detection sensitivity, accuracy and biocompatibility. This review article highlights recent progress on stimuli‐responsive materials with mixed valence species, viologens, twisting chirality, crystalline/amorphous, sol‐gel phase transitions and resulting supramolecular nanostructures via non‐covalent interactions. These materials can be applied in flexible electronics, drug delivery, detection of pollutants and bioimaging. Thus, the demand for widespread research on development of stimuli‐responsive materials are requisite to resolve the challenges pertaining to stability and sensitivity of devices for design in comprehensive technology.

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“…Finally, Huang et al reported a hydrogel system that is responsive to ATP. Hydrogel D15 was formed from the self-assembly between a TPE derivative containing two quaternary ammonium groups, and poly(sodium p -styrenesulfonate) [114]. Self-assembly caused RIR of the TPE moieties, leading to the hydrogel with bright blue fluorescence.…”

Section: Sensing Of Phosphorus-containing Anionsmentioning

confidence: 99%

“…When ATP was added, it competitively interacted with the two quaternary ammonium groups in the TPE derivatives via electrostatic interactions, disassembled the hydrogel and eventually quenched blue emission. The above process can however be reversed with addition of phosphatase, which hydrolyses ATP, thereby reinstating the formation of hydrogel D15 [114] . This type of hydrogel is biocompatible and could enter cell cytoplasm for biosensing of ATP in HEK293 cell lines.…”

Section: Sensing Of Phosphorus-containing Anionsmentioning

confidence: 99%

Recent Advances in Aggregation-Induced Emission Chemosensors for Anion Sensing

et al. 2019

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The discovery of the aggregation-induced emission (AIE) phenomenon in the early 2000s not only has overcome persistent challenges caused by traditional aggregation-caused quenching (ACQ), but also has brought about new opportunities for the development of useful functional molecules. Through the years, AIE luminogens (AIEgens) have been widely studied for applications in the areas of biomedical and biological sensing, chemosensing, optoelectronics, and stimuli responsive materials. Particularly in the application of chemosensing, a myriad of novel AIE-based sensors has been developed to detect different neutral molecular, cationic and anionic species, with a rapid detection time, high sensitivity and high selectivity by monitoring fluorescence changes. This review thus summarises the recent development of AIE-based chemosensors for the detection of anionic species, including halides and halide-containing anions, cyanides, and sulphur-, phosphorus- and nitrogen- containing anions, as well as a few other anionic species, such as citrate, lactate and anionic surfactants.

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An ATP/ATPase responsive supramolecular fluorescent hydrogel constructedviaelectrostatic interactions between poly(sodiump-styrenesulfonate) and a tetraphenylethene derivative

Abstract: We report a supramolecular fluorescent hydrogel based on poly(sodiump-styrenesulfonate) and a tetraphenylethene derivative.

Cited by 61 publications

References 71 publications

Thermo-Switchable de Novo Ionic Liquid-Based Gelators with Dye-Absorbing and Drug-Encapsulating Characteristics

Thermo-Switchable de Novo Ionic Liquid-Based Gelators with Dye-Absorbing and Drug-Encapsulating Characteristics

Recent Advances on Stimuli‐Responsive Smart Materials and their Applications

Recent Advances in Aggregation-Induced Emission Chemosensors for Anion Sensing

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