An Atlas of Protein Phosphorylation Dynamics During Interferon Signaling
Idoia Busnadiego,
Marie Lork,
Sonja Fernbach
et al.
Abstract:Interferons (IFNs, types I-III) have pleiotropic functions in promoting antiviral and anti-tumor responses, as well as in modulating inflammation. Dissecting the signaling mechanisms elicited by different IFNs is therefore critical to understand their phenotypes. Here, we use mass spectrometry to investigate the early temporal dynamics of cellular protein phosphorylation in response to stimulation with IFNα2, IFNβ, IFNω, IFNγ, and IFNλ1, representing all IFN types. We report an atlas of over 700 common or uniq… Show more
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