An atlas of nano-enabled neural interfaces

Ledesma, Héctor Acarón; Li, Xiaojian; Carvalho-de-Souza, João L.; Wei, Wei; Bezanilla, Francisco; Tian, Bozhi

doi:10.1038/s41565-019-0487-x

Cited by 142 publications

(84 citation statements)

References 148 publications

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“…The precise, fast, and efficient spatiotemporal control of cellular signaling via the use of external triggers has become an important topic in chemical biology1 and photopharmacology 2,3. In this regard, light‐responsive systems offer the possibility to employ light as a clean, non‐invasive, and spatio‐temporally precise tool for controlling a variety of biological signals both in vitro and in vivo 4–9. A plethora of photochromic systems allowing modulation of molecular responses in a reversible fashion have been developed 10,11.…”

Section: Figurementioning

confidence: 99%

Membrane Environment Enables Ultrafast Isomerization of Amphiphilic Azobenzene

et al. 2020

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The non‐covalent affinity of photoresponsive molecules to biotargets represents an attractive tool for achieving effective cell photo‐stimulation. Here, an amphiphilic azobenzene that preferentially dwells within the plasma membrane is studied. In particular, its isomerization dynamics in different media is investigated. It is found that in molecular aggregates formed in water, the isomerization reaction is hindered, while radiative deactivation is favored. However, once protected by a lipid shell, the photochromic molecule reacquires its ultrafast photoisomerization capacity. This behavior is explained considering collective excited states that may form in aggregates, locking the conformational dynamics and redistributing the oscillator strength. By applying the pump probe technique in different media, an isomerization time in the order of 10 ps is identified and the deactivation in the aggregate in water is also characterized. Finally, it is demonstrated that the reversible modulation of membrane potential of HEK293 cells via illumination with visible light can be indeed related to the recovered trans→cis photoreaction in lipid membrane. These data fully account for the recently reported experiments in neurons, showing that the amphiphilic azobenzenes, once partitioned in the cell membrane, are effective light actuators for the modification of the electrical state of the membrane.

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Section: Figurementioning

confidence: 99%

Membrane Environment Enables Ultrafast Isomerization of Amphiphilic Azobenzene

et al. 2020

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“…Until now, commercial wearable sensors have forms that add sensor functions to existing portable electronic systems with rigid forms. Therefore, numerous research of wearable sensing systems has shown that they can intimately contact the surface of body parts or be implanted into the body with minimal damage to biological tissue; examples include stretchable electronic skin [8], soft neural interfaces with tissue-level stiffness [9], and smart contact lenses fabricated on the soft contact lens materials for minimal eye irritation [10]. In addition to the development of stretchable or transparent wearable sensors that minimize discomfort to users [11,12,13,14], one of the main research goals of wearable sensing devices is the continuous detection of biological signals while being attached or implanted into the user’s body.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Wireless Sensors for Wearable Electronics

Park

2019

Sensors

109

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The development of wearable electronics has emphasized user-comfort, convenience, security, and improved medical functionality. Several previous research studies transformed various types of sensors into a wearable form to more closely monitor body signals and enable real-time, continuous sensing. In order to realize these wearable sensing platforms, it is essential to integrate wireless power supplies and data communication systems with the wearable sensors. This review article discusses recent progress in wireless technologies and various types of wearable sensors. Also, state-of-the-art research related to the application of wearable sensor systems with wireless functionality is discussed, including electronic skin, smart contact lenses, neural interfaces, and retinal prostheses. Current challenges and prospects of wireless sensor systems are discussed.

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“…Enhancing conformability has been proven to increase the electrophysiological signals sensing sensitivity . The conformal contact of device on epidermis helps the formation of the conductive signals transduction pathway . Apart from the aforementioned conformable contact in the biomechanical signal testing, conformal functional elements should also exhibit ionic or electrical conductivity to transduce electrophysiological signals.…”

Section: Stretchable and Conformal Sensors For Cyber Biophysical Intementioning

confidence: 99%

Cyber–Physiochemical Interfaces

et al. 2020

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Living things rely on various physical, chemical, and biological interfaces, e.g., somatosensation, olfactory/gustatory perception, and nervous system response. They help organisms to perceive the world, adapt to their surroundings, and maintain internal and external balance. Interfacial information exchanges are complicated but efficient, delicate but precise, and multimodal but unisonous, which has driven researchers to study the science of such interfaces and develop techniques with potential applications in health monitoring, smart robotics, future wearable devices, and cyber physical/human systems. To understand better the issues in these interfaces, a cyber–physiochemical interface (CPI) that is capable of extracting biophysical and biochemical signals, and closely relating them to electronic, communication, and computing technology, to provide the core for aforementioned applications, is proposed. The scientific and technical progress in CPI is summarized, and the challenges to and strategies for building stable interfaces, including materials, sensor development, system integration, and data processing techniques are discussed. It is hoped that this will result in an unprecedented multi‐disciplinary network of scientific collaboration in CPI to explore much uncharted territory for progress, providing technical inspiration—to the development of the next‐generation personal healthcare technology, smart sports‐technology, adaptive prosthetics and augmentation of human capability, etc.

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An atlas of nano-enabled neural interfaces

Cited by 142 publications

References 148 publications

Membrane Environment Enables Ultrafast Isomerization of Amphiphilic Azobenzene

Membrane Environment Enables Ultrafast Isomerization of Amphiphilic Azobenzene

Recent Progress in Wireless Sensors for Wearable Electronics

Cyber–Physiochemical Interfaces

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