An Association of Chitinase-3 Like-Protein-1 With Neuronal Deterioration in Multiple Sclerosis

Ahmad, Intakhar; Wergeland, Stig; Oveland, Eystein; Bø, Lars

doi:10.1177/17590914231198980

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…In 2010, Comabella et al identified that CHI3L1 seems to be a prognostic biomarker for conversion to MS and development of disability utilizing the previously collected cerebrospinal fluid samples from MS patients by a mass spectrometry-based proteomic approach validating with ELISA (enzyme-linked immunosorbent assay) [75]. Positively associated elevation of CHI3L1 in MS samples was followed/reviewed by many other groups so far [27][28][29][30][31][32][33][34][35][76][77][78].…”

Section: Multiple Sclerosis (Ms)mentioning

confidence: 99%

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Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation

Mizoguchi,

Sadanaga,

Nanni

et al. 2024

Cells

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Chitinase 3-like 1 (also known as CHI3L1 or YKL-40) is a mammalian chitinase that has no enzymatic activity, but has the ability to bind to chitin, the polymer of N-acetylglucosamine (GlcNAc). Chitin is a component of fungi, crustaceans, arthropods including insects and mites, and parasites, but it is completely absent from mammals, including humans and mice. In general, chitin-containing organisms produce mammalian chitinases, such as CHI3L1, to protect the body from exogenous pathogens as well as hostile environments, and it was thought that it had a similar effect in mammals. However, recent studies have revealed that CHI3L1 plays a pathophysiological role by inducing anti-apoptotic activity in epithelial cells and macrophages. Under chronic inflammatory conditions such as inflammatory bowel disease and chronic obstructive pulmonary disease, many groups already confirmed that the expression of CHI3L1 is significantly induced on the apical side of epithelial cells, and activates many downstream pathways involved in inflammation and carcinogenesis. In this review article, we summarize the expression of CHI3L1 under chronic inflammatory conditions in various disorders and discuss the potential roles of CHI3L1 in those disorders on various cell types.

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Section: Multiple Sclerosis (Ms)mentioning

confidence: 99%

“…[ [27][28][29][30][31][32][33][34][35] Neuron (AD) 1 ⃝ 4 ⃝ CSF (<5 folds in adults), Tissue(<10 folds ↑in adults)…”

mentioning

confidence: 99%

Identification of distinct and shared biomarker panels in different manifestations of cerebral small vessel disease through proteomic profiling

Hristovska,

Binette,

Kumar

et al. 2024

Preprint

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The pathophysiology underlying various manifestations of cerebral small vessel disease (cSVD) remains obscure. Using cerebrospinal fluid proximity extension assays and co-expression network analysis of 2,943 proteins, we found common and distinct proteomic signatures between white matter lesions (WML), microbleeds and infarcts measured in 856 living patients, and validated WML-associated proteins in three additional datasets. Proteins indicative of extracellular matrix dysregulation and vascular remodeling, including ELN, POSTN, CCN2 and MMP12 were elevated across all cSVD manifestations, with MMP12 emerging as an early cSVD indicator. cSVD-associated proteins formed a co-abundance network linked to metabolism and enriched in endothelial and arterial smooth muscle cells, showing elevated levels at early disease manifestations. Later disease stages involved changes in microglial proteins, associated with longitudinal WML progression, and changes in neuronal proteins mediating WML-associated cognitive decline. These findings provide an atlas of novel cSVD biomarkers and a promising roadmap for the next generation of cSVD therapeutics.

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Recently updated role of Chitinase 3-like 1 on various cell types as a major infuencer of chronic inflammation

Mizoguchi,

Sadanaga,

Nanni

et al. 2024

Preprint

View full text Add to dashboard Cite

Chitinase 3-like 1 （also known as CHI3L1 or YKL-40）is a mammalian chitinase that has no enzymatic activity, but has the ability to bind to chitin, the polymer of N-acetylglucosamine (GlcNAc). Chitin is a component of fungi, crustaceans, arthropods including insects and mites, and parasites, but is completely absent from mammals, including humans and mice. In general, chitin-containing organisms produce CHI3L1 to protect the body from exogenous pathogen as well as hostile environments, and it was thought that it has a similar effect in mammals. However, recent studies have revealed that CHI3L1 plays a pro-inflammatory role by inducing anti-apoptotic activity in epithelial cells and macrophages. Under chronic inflammatory conditions such as inflammatory bowel disease and chronic obstructive pulmonary disease, many groups already confirmed that the expression of CHI3L1 is significantly induced on the apical side of epithelial cells, and activates many downstream pathways involved in inflammation and carcinogenesis. In this review article, we will summarize the expression of CHI3L1 under the chronic inflammatory conditions in various disorders and would like to discuss the potential roles of CHI3L1 in those disorders on various cell types.

show abstract

An Association of Chitinase-3 Like-Protein-1 With Neuronal Deterioration in Multiple Sclerosis

Cited by 3 publications

References 46 publications

Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation

Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation

Identification of distinct and shared biomarker panels in different manifestations of cerebral small vessel disease through proteomic profiling

Recently updated role of Chitinase 3-like 1 on various cell types as a major infuencer of chronic inflammation

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