An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

Vašků, Anna; Souček, Miroslav; Tschöplová, Svatava; Stejskalová, Andrea

doi:10.1038/sj.jhh.1001409

Cited by 18 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The final result were nine studies (Iso et al , 2000; Sato et al , 2000; Vasku et al , 2002; Wang et al , 2002; Nair et al , 2003; Tsai et al , 2003; Nejatizadeh et al .,2008; Jiang et al , 2009; Yuan et al , 2009). These involved 2188 essential hyper cases and 2459 controls, and by meeting the inclusion criteria they were included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis

et al. 2014

View full text Add to dashboard Cite

The association between T174M polymorphism of angiotensinogen gene and essential hypertension risk remains controversial. We herein performed a meta-analysis to achieve a reliable estimation of their relationship. All the studies published up to May 2013 on the association between T174M polymorphism and essential hypertension risk were identified by searching the electronic repositories PubMed, MEDLINE and EMBASE, Springer, Elsevier Science Direct, Cochrane Library and Google Scholar. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Ultimately, nine eligible studies, including 2188 essential hypertension cases and 2459 controls, were enrolled in this meta-analysis. No significant associations were found under the overall ORs for M-allele comparison (M vs. T, pooled OR 0.92, 95% CI 0.62–1.37), MM vs. TT (pooled OR 0.86, 95% CI 0.29–2.51), TM vs. TT n (pooled OR 0.91, 95% CI 0.63–1.32), recessive model (MM vs. TT+TM, pooled OR 0.89, 95% CI 0.35–2.30), dominant model (MM+TM vs. TT, pooled OR 0.91, 95% CI 0.60–1.38) between T174M polymorphism and risk for essential hypertension. This meta-analysis suggested that the T174M polymorphism of the angiotensinogen gene might not be associated with the susceptibility of essential hypertension in Asian or European populations.

show abstract

Section: Resultsmentioning

confidence: 99%

Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…A study made by our group revealed the effect of AGT genetic variants (rs4762, rs699 and rs5051) on BMI in hypertensive patients; however, the distribution patterns of body fat were not investigated (Vasků et al 2002). The only study so far evaluating the effect of miRNA binding site ?11525 C/A (rs7079) on BMI was performed by Al-Najai et al In accordance with our results, no association with BMI was found; however, the polymorphism was associated with hypertension and coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

et al. 2015

View full text Add to dashboard Cite

Angiotensinogen (AGT), its active fragments and microRNA-31 (miR-31) play an important role in adipocyte differentiation. AGT contains a miR-31 polymorphic binding site. We hypothesize that the rs7079 polymorphism in the miR-31/584 binding site of the AGT gene could influence body fat distribution. A total of 751 subjects (195 men, 556 women) were enrolled in the study. The rs7079 genotypes were determined by qRT-PCR. Anthropometric measurements were taken on all subjects, who were subsequently divided into two groups: obese ([30 kg m -2 ) and non-obese (\30 kg m -2 ). Linear regression models were created to determine the contributions of sex, obesity status and rs7079 to all measured parameters. Adding the rs7079 genotype significantly contributed to the linear regression model for waist circumference (p = 0.013), hip circumference (p = 0.018) and supraspinal skin-fold thickness (p = 1 9 10 -3 ). Differences between sexes and between the obese and nonobese groups were observed. Waist circumference was lower in men carrying the A allele (p = 0.022); hip circumference was higher only in obese women carrying the A allele (p = 0.015). While men carrying the A allele had lower supraspinal skin-fold thickness (p = 0.022), this parameter was found to be higher in A allele carrying women (p = 3 9 10 -3 ). The higher total sum of skin-fold thickness in A allele carrying women was restricted to obese individuals (p = 0.028). The presence of the A allele was associated with both lower tricipital skin-fold thickness in non-obese women (p = 0.023) and a trend of higher thickness in non-obese men (p = 0.065). Significant associations of rs7079 in the AGT gene and body fat distribution were observed. The distribution followed opposing patterns in both sexes.

show abstract

“…The AGT M235T gene polymorphism, which is correlated with circulating and cellular AGT concentrations, has been implicated in ESRD etiology and investigated in epidemiologic studies [18, 19]. The AGTR1 gene was independently associated with renal disease progression and cardiovascular disease [20, 21]. Several studies reported that ACE serum and plasma levels were influenced by ACE I/D [22] and G2350A [23] polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

Gene-Gene Interactions in Renin-Angiotensin-Aldosterone System Contributes to End-Stage Renal Disease Susceptibility in a Han Chinese Population

Yang

et al. 2014

The Scientific World Journal

View full text Add to dashboard Cite

Objective. In this study, we investigated whether RAAS gene single nucleotide polymorphisms (SNPs) and their interactions were associated with end-stage renal stage (ESRD). Methodology and Results. This was a case-control study for 647 ESRD cases and 644 controls. AGT (M235T (rs699) and T174M (rs4762)), AGTR1 (A1166C (rs5186) and C573T (rs5182)), ACE (I/D (rs1799752) and G2350A (rs4343)), and CYP11B2 C-344T (rs1799998) were genotyped and compared between cases and controls to identify SNPs associated with ESRD susceptibility. Multifactor dimensionality reduction (MDR) was used to identify gene-gene interactions. Several RAAS genes were associated with ESRD: AGT M235T, ACE I/D, ACE G2350A, and CYP11B2 C-344T. By MDR analysis, a three-locus model (ACE ID/ACE G2350A/CYP11B2 C-344T) of gene-gene interaction was the best for predicting ESRD risk, and its maximum testing accuracy was 56.08% and maximum cross-validation consistency was 9/10. ESRD risk was higher with the simultaneous occurrence of ACE I/D DD-ACE G2350A AA. AGT, ACE, and CYP11B2 gene polymorphisms are associated with ESRD. Conclusions. The gene-gene interaction effects of ACE I/D, ACE G2350A, and CYP11B2 C-344T polymorphisms are more important than individual factors for ESRD development among Han Chinese.

show abstract

An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

Cited by 18 publications

References 20 publications

Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis

Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Gene-Gene Interactions in Renin-Angiotensin-Aldosterone System Contributes to End-Stage Renal Disease Susceptibility in a Han Chinese Population

Contact Info

Product

Resources

About