An association between type 1 diabetes and idiopathic generalized epilepsy

Abstract

Our results suggest that the prevalence of T1D is increased by a factor of four in young adults with IGE. To our knowledge, this is the first published association between the two conditions and expands the diseases known to be associated with T1D.

Risk of epilepsy in type 1 diabetes mellitus: a population-based cohort study

“…Few studies have epidemiologically analysed the association between type 1 diabetes and epilepsy. McCorry et al found a significant surplus of type 1 diabetes in an idiopathic generalised epilepsy cohort, with an OR of 4.4 [18]. However, O'Connell et al could not confirm these results; after examining the type of epilepsy and prevalence in children and adolescents with type 1 diabetes, they found no difference compared with those in the general paediatric population [19].…”

Autoimmune Diseases Associated with Epilepsy

“…[106] Tip1DM'si olan 518 vakalık bir seride 7 hastada, ya juvenil miyoklonik epilepsi ya da jeneralize tonik klonik nöbetler görülmüş; ve epilepsi insidansının (1,6:1.000) kontrol popü-lasyonuna göre beklenenin üstünde olduğu bildirilmiştir. [107] Diyabetik pediyatrik 1384 hastalık kohortta yapılan çalışma-da epilepsi prevalansının %0,9 olduğu bulunmuş ve genel popülasyon ile benzer oranlar görüldüğü bildirilmiştir. [106] Kontrol grubunun olmadığı daha az sayıda hasta ile yapılan başka bir çalışmada ise %2,4 gibi yüksek bir prevalans bildirilmiştir.…”

MECHANISMS IN ENDOCRINOLOGY: Seizures and type 1 diabetes mellitus: current state of knowledge

“…The two conditions have been observed in individuals more frequently than might be expected by chance (7). This review discusses current understanding of the possible coexistence between seizures or epilepsy and diabetes mellitus in relation to autoimmunity, electroencephalogram (EEG) abnormalities, and glycemic variations, in order to establish if there is more than a casual association, and to investigate possible mechanisms underlying this link.…”

“…The high proportion of IGE observed (four of 249, 1.6%) supports the data of McCorry et al In all patients but one, the epilepsy onset was preceded by T1DM with a mean of 2.8 years. This may reflect different age of onset of the two conditions or alternatively, it could support an autoimmune mechanism starting with T1DM and, then, affecting the CNS (7,10). On the other hand, it is possible that recurrent episodes of hypoglycemia can result in seizures.…”