An association between asthma and TNF-308G/A polymorphism: meta-analysis

Aoki, Takeshi; Hirota, Tomomitsu; Tamari, Mayumi; Ichikawa, Kunio; Takeda, Kazunori; Arinami, Tadao; Shibasaki, Masanao; Noguchi, Emiko

doi:10.1007/s10038-006-0007-3

Cited by 58 publications

(34 citation statements)

References 46 publications

(63 reference statements)

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“…It also appears that anti-TNF-␣ therapy is most effective in patients with more severe disease, which is consistent with the present study, in which we demonstrated that different levels of TNF-␣ in airways between C57BL/6 and BALB/c mice directly correlated with the intensity of AHR in these strains of mice (47). Furthermore, polymorphisms in the TNF-␣ gene have been associated with asthma severity and risk (2,18,26), and TNF-␣ variants have been shown to lead to altered levels of TNF-␣ protein in patients and were associated with asthma incidence (5,43). These collective findings, along with our present observations, suggest that TNF-␣ may be an important target in the treatment of asthma (19).…”

Section: Discussionsupporting

confidence: 92%

Strain-dependent activation of NF-κB in the airway epithelium and its role in allergic airway inflammation

Alcorn

Ckless

Brown³

et al. 2010

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussionsupporting

confidence: 92%

Strain-dependent activation of NF-κB in the airway epithelium and its role in allergic airway inflammation

Alcorn

Ckless

Brown³

et al. 2010

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…This inversion explains ∼40% of the population-attributable risk for joint susceptibility to obesity and asthma. Additional genes including the β2-adrenergic receptor gene (ADRB2), 148,149 the TNF gene, 150,151 and the lymphotoxin-α (LTA) gene 152,153 have been associated in both obesity and asthma in children. However, the limited number of these studies highlights the paucity of data on genetic susceptibility for obesity-related asthma.…”

Section: Genetics Of Obesity-related Asthmamentioning

confidence: 99%

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation

2016

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The burden of obesity-related asthma among children, particularly among ethnic minorities, necessitates an improved understanding of the underlying disease mechanisms. Although obesity is an independent risk factor for asthma, not all obese children develop asthma. Several recent studies have elucidated mechanisms, including the role of diet, sedentary lifestyle, mechanical fat load, and adiposity-mediated inflammation that may underlie the obese asthma pathophysiology. Here, we review these recent studies and emerging scientific evidence that suggest metabolic dysregulation may play a role in pediatric obesity-related asthma. We also review the genetic and epigenetic factors that may underlie susceptibility to metabolic dysregulation and associated pulmonary morbidity among children. Lastly, we identify knowledge gaps that need further exploration to better define pathways that will allow development of primary preventive strategies for obesity-related asthma in children.

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“…[58]. Nonetheless, genetic polymorphism of the TNF-α gene on chromosome 6 is associated with asthma, asthma severity and BHR [59].…”

Section: Role Of Tnf-α In Asthma and Copdmentioning

confidence: 99%

TNF-α inhibitors in asthma and COPD: We must not throw the baby out with the bath water

Matera

Calzetta

Cazzola

2010

Pulmonary Pharmacology & Therapeutics

117

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Tumor necrosis factor (TNF)-α, a pleiotropic cytokine that exerts a variety of effects, such as growth promotion, growth inhibition, angiogenesis, cytotoxicity, inflammation, and immunomodulation, has been implicated in several inflammatory conditions. It plays a significant role in many inflammatory diseases of lung. Given that there is significant literature supporting the pathobiologic role of TNF-α in asthma, mainly in severe refractory asthma, and COPD, TNF-α inhibitors (infliximab, golimumab and etanercept) are now regarded as potential new medications in asthma and COPD management. The studies reported in literature indicate that TNF-α inhibitors are effective in a relatively small subgroup of patients with severe asthma, possibly defined by an increased TNF axis, but they seem to be ineffective in COPD, although an observational study demonstrated that TNF-α inhibitors were associated with a reduction in the rate of COPD hospitalisation among patients with COPD receiving these agents to treat their rheumatoid arthritis. These findings require a smart approach because there is still good reason to target TNF-α, perhaps in a more carefully selected patient group. TNF-α treatment should therefore not be thrown out, or abandoned. Indeed, since severe asthma and COPD are heterogeneous diseases that have characteristics that occur with different phenotypes remained poorly characterized and little known about the underlying pathobiology contributing to them, it is likely that definition of these phenotypes and choice of the right outcome measure will allow us to understand which kind of patients can benefit from TNF-α inhibitors.

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An association between asthma and TNF-308G/A polymorphism: meta-analysis

Cited by 58 publications

References 46 publications

Strain-dependent activation of NF-κB in the airway epithelium and its role in allergic airway inflammation

Strain-dependent activation of NF-κB in the airway epithelium and its role in allergic airway inflammation

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation

TNF-α inhibitors in asthma and COPD: We must not throw the baby out with the bath water

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