In this study, we used minute gas-liquid interfaces around CO 2 microbubbles activated by microwave irradiation as new reaction fields and developed a crystallization technique to produce lithium carbonate (Li 2 CO 3 ) nanoparticles. At the minute gas-liquid interfaces, nucleation occurs predominantly because of the formation of numerous local supersaturation regions at higher temperatures; hence, fine-sized Li 2 CO 3 particles with a narrow size distribution are crystallized, as the Li 2 CO 3 solubility decreases sharply with an increase in temperature. Microwaves (2.45 GHz) were used to irradiate an aqueous solution containing lithium ions and CO 2 microbubbles in a waveguide-type microwave apparatus. The heating method, rate of temperature increase (r T r T r T ) and average bubble size (d bbl d bbl d bbl ) were considered as the operation parameters and varied; the combined effects of CO 2 microbubble formation and microwave irradiation on the reactive crystallization of Li 2 CO 3 nanoparticles were examined. Consequently, during microwave irradiation of the solution containing CO 2 microbubbles, the crystallization of Li 2 CO 3 nanoparticles was significantly accelerated with an increase in r T r T r T and a decrease in