An assessment of the performance of the probabilistic genotyping software EuroForMix: Trends in likelihood ratios and analysis of Type I &amp; II errors

Benschop, Corina C.G.; Nijveld, Alwart; Duijs, Francisca E.; Sijen, Titia

doi:10.1016/j.fsigen.2019.06.005

Cited by 40 publications

(40 citation statements)

References 25 publications

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“…Overestimating tends to produce false positive support for non-donors, usually at relatively low LRs. The larger template donors are much more stable with respect to different NOC [70][71][72][73].…”

Section: Number Of Contributors (Noc)mentioning

confidence: 99%

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A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™

Gill

Benschop

Buckleton

et al. 2021

Genes

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Probabilistic genotyping has become widespread. EuroForMix and DNAStatistX are both based upon maximum likelihood estimation using a γ model, whereas STRmix™ is a Bayesian approach that specifies prior distributions on the unknown model parameters. A general overview is provided of the historical development of probabilistic genotyping. Some general principles of interpretation are described, including: the application to investigative vs. evaluative reporting; detection of contamination events; inter and intra laboratory studies; numbers of contributors; proposition setting and validation of software and its performance. This is followed by details of the evolution, utility, practice and adoption of the software discussed.

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Section: Number Of Contributors (Noc)mentioning

confidence: 99%

“…This folder contains laboratory data from derived samples of three person mixtures using the 'PowerPlex ® Fusion 6C' kit and Dutch database frequencies from a study by Benschop et al [73]. To explore whether closely related individuals will give a high LR when Mr X is substituted by a sibling, we specify following propositions:…”

Section: Relatednessmentioning

confidence: 99%

A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™

Gill

Benschop

Buckleton

et al. 2021

Genes

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show abstract

“…Greenspoon et al [12] report the ability of TrueAllele to differentiate the true donor from first degree relatives. Contrastingly, Benschop et al [13] found a high rate of type II errors with EuroForMix when relatives of a true donor were considered.…”

Section: Introductionmentioning

confidence: 87%

The interpretation of mixed DNA profiles from a mother, father, and child trio

Lin

Bright

Pugh³

et al. 2020

Forensic Science International: Genetics

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“…Laboratory-generated 2p-5p PPF6C profiles from [3] were used to test how well the corrected TACs of simulated PPF6C profiles are informative on the NOC. These profiles represent a variety of mixtures with variation for genotypes (n = 30 different donors), mixture proportion, drop-out and allele sharing.…”

Section: Methodsmentioning

confidence: 99%