An assessment of the immunological environment based on intratumoral cytokine production in renal cell carcinoma

Abstract

Objective To assess the immunological relationship whom showed a higher level than the mean, and IL-6 was produced in 32 (91%) of whom 10 (29%) showed between tumour and host, focusing on the production of T-cell helper (Th) subset-derived cytokines in a higher level than the mean. IL-10 was detected in 28 patients (80%) of whom 14 (40%) showed a higher patients with renal cell carcinoma (RCC). Patients and methods The study comprised 35 patients level than the mean. The production of these cytokines was closely related to the stage and grade of malig-(19 men and 16 women, mean age 56.9 years, range 39-78) with RCC, who had undergone nephrectomy.nancy. Furthermore, there were significant correlations between the levels of production of IL-4 and Using enzyme-linked immunosorbent assays, the levels of Th1-derived cytokines were measured, including IL-5 (r2=0.92), IL-4 and IL-10 (r2=0.91), and IL-5 and IL-10 (r2=0.85). interleukin (IL)-2 and interferon (IFN)-c, and Th2-derived cytokines, including IL-4, IL-5, IL-6, Conclusion The intratumoral immunological environment in patients with RCC shows a tendency to IL-10 and others. Results There was no detectable IL-2 or IFN-c proproduce Th2-related cytokines in accordance with the stage and grade; this suggests a role in humoral but duction (below the detection limit) except in two patients; IL-4 was produced in 18 patients (51%) and not in cellular immunity. Keywords Renal cell carcinoma, immunity, T helper of these, 15 (43%) showed a higher level than the mean. IL-5 was produced in 12 patients (34%), all of subset, cytokine cytokines in patients with RCC. Based upon the results,

Interleukin-6, Interleukin-10 and Heat Shock Protein-90 Expression in Renal Epithelial Neoplasias and Surrounding Normal-Appearing Renal Parenchyma

“…Recent studies in the peripheral blood showed higher IL-6 and IL-IO levels in patients with RCC than in healthy control s (38), and a positive correlation between IL-6 and IL-l 0 plasma levels, tumor size, tumor progression and prognosis (4,26,(38)(39)(40)(41)(42) . In their study investigating IL-IO expression in human RCC, Uwatoko et al (37) reported a decreased incidence of metastasis in patients with IL-IO levels than in those without IL-IO, and no correlation between IL-I 0 expression and prognosis.…”

Sunitinib Reverses Type-1 Immune Suppression and Decreases T-Regulatory Cells in Renal Cell Carcinoma Patients

“…The diminished type-1 response in RCC patients is not limited to MAGE-6 -specific and EphA2-specific CD4 + T cells. Following polyclonal activation, Onishi et al (9) showed that the peripheral blood lymphocyte response changes from predominantly type 1 to type 2 with advancing stage of RCC.…”

Paradoxical Roles of IL-4 in Tumor Immunity

“…They found IL-4, as well as other Th2 cytokines, was usually up-regulated in patients with different types of cancers, such as renal cell cancer, non-small lung cancer, prostate cancer, colon cancer, breast cancer and other types of tumors (15). Onishi et al even found the IL-4 amount at tumor site was associated with the stage and grade of renal cancer (16).…”