An assessment of the effectiveness of hyaluronic acid and polyacrylamide hydrogel in horses with osteoarthritis: Systematic review and network meta-analysis

Xavier, Amanda Azambuja da Silva; Rosa, Patrícia Pinto da; Mackmill, Laurett de Brum; Roll, Victor Fernando Büttow

doi:10.1016/j.rvsc.2020.11.013

Cited by 5 publications

(6 citation statements)

References 45 publications

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“…At the specific time point, the supernatant was removed and the weight of the swollen hydrogels (W s ) was measured. The swelling ratio (%) was calculated using formula (1).…”

Section: Swelling Ratio (%)mentioning

confidence: 99%

“…The pristine SF exhibited characteristic peaks at 3300 cm⁻ 1 (-NH stretching group), 1636 cm⁻ 1 (amide I), 1556 cm⁻ 1 (amide II), and 1232 cm⁻ 1 (amide III) [42]. SF crosslinked with EDC-NHS (ENSF) showed a strong peak at 1716 cm⁻ 1 , an amide group that confirms chemical crosslinking between the carboxyl group of SF and the amine group of EDC [43]. The 0.3% GG/3.7% SF/CS, 0.5% GG/3.5% SF/CS, 0.75% GG/3.25% SF/CS, and 1% GG/3% SF/CS hydrogels displayed characteristic peaks at 3302 cm⁻ 1 , 3302 cm⁻ 1 , 3306 cm⁻ 1 , and 3303 cm⁻ 1 (-OH and -NH stretching); 1634 cm⁻ 1 , 1634 cm⁻ 1 , 1633 cm⁻ 1 , and 1634 cm⁻ 1 (amide I); 1557 cm⁻ 1 , 1557 cm⁻ 1 , 1563 cm⁻ 1 , and 1563 cm⁻ 1 (amide II); 1221 cm⁻ 1 , 1227 cm⁻ 1 , 1229 cm⁻ 1 , and 1226 cm⁻ 1 (amide III); and 1026 cm⁻ 1 , 1030 cm⁻ 1 , 1029 cm⁻ 1 , and 1029 cm⁻ 1 (-COC stretching).…”

Section: Ft-ir Analysismentioning

confidence: 99%

“…One of the major challenges faced by developed societies today is the transition to a much older population. Due to population aging, osteoarthritis (OA) is a challenge and priority in healthcare systems around the world [1]. Severely damaged cartilage is difficult to self-recover due to its avascular, aneural, and nonlymphatic properties, and it leads to OA [2].…”

Section: Introductionmentioning

confidence: 99%

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Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

et al. 2021

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Hydrogel is in the spotlight as a useful biomaterial in the field of drug delivery and tissue engineering due to its similar biological properties to a native extracellular matrix (ECM). Herein, we proposed a ternary hydrogel of gellan gum (GG), silk fibroin (SF), and chondroitin sulfate (CS) as a biomaterial for cartilage tissue engineering. The hydrogels were fabricated with a facile combination of the physical and chemical crosslinking method. The purpose of this study was to find the proper content of SF and GG for the ternary matrix and confirm the applicability of the hydrogel in vitro and in vivo. The chemical and mechanical properties were measured to confirm the suitability of the hydrogel for cartilage tissue engineering. The biocompatibility of the hydrogels was investigated by analyzing the cell morphology, adhesion, proliferation, migration, and growth of articular chondrocytes-laden hydrogels. The results showed that the higher proportion of GG enhanced the mechanical properties of the hydrogel but the groups with over 0.75% of GG exhibited gelling temperatures over 40 °C, which was a harsh condition for cell encapsulation. The 0.3% GG/3.7% SF/CS and 0.5% GG/3.5% SF/CS hydrogels were chosen for the in vitro study. The cells that were encapsulated in the hydrogels did not show any abnormalities and exhibited low cytotoxicity. The biochemical properties and gene expression of the encapsulated cells exhibited positive cell growth and expression of cartilage-specific ECM and genes in the 0.5% GG/3.5% SF/CS hydrogel. Overall, the study of the GG/SF/CS ternary hydrogel with an appropriate content showed that the combination of GG, SF, and CS can synergistically promote articular cartilage defect repair and has considerable potential for application as a biomaterial in cartilage tissue engineering.

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“…At the specific time point, the supernatant was removed and the weight of the swollen hydrogels (W s ) was measured. The swelling ratio (%) was calculated using formula (1).…”

Section: Swelling Ratio (%)mentioning

confidence: 99%

Section: Ft-ir Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

et al. 2021

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“…It also limits the progression of OA lesions by stabilizing proteoglycan structure, limiting the enzymatic breakdown associated with degenerative arthritis [101]. HyA improves the viscosity of synovial fluid (SF), helping its physiological function by acting as a buffer and stabilizer of lubrication and as an anti-inflammatory and analgesic due to increased joint lubrication, resulting in decreased pain in unstable joints [102]. Treatment can be carried out IA, IV, or PO, with IA being more effective.…”

Section: Hyaluronic Acid (Hya)mentioning

confidence: 99%

“…In the past, evidence has demonstrated that the IA injection of HyA and SAIDs improved the performance of race horses with traumatic arthritis, and since then, this association has been widely used [105]. However, there is no scientific evidence that hyaluronic acid combined or not with anti-inflammatory drugs is effective in the long run, and that the association with SAIDs is more effective in reducing lameness than HyA itself [102].…”

Section: Hyaluronic Acid (Hya)mentioning

confidence: 99%

Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review

Reis,

Lopes,

Sousa

et al. 2024

Veterinary Sciences

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Musculoskeletal injuries such as equine osteoarthritis, osteoarticular defects, tendonitis/desmitis, and muscular disorders are prevalent among sport horses, with a fair prognosis for returning to exercise or previous performance levels. The field of equine medicine has witnessed rapid and fruitful development, resulting in a diverse range of therapeutic options for musculoskeletal problems. Staying abreast of these advancements can be challenging, prompting the need for a comprehensive review of commonly used and recent treatments. The aim is to compile current therapeutic options for managing these injuries, spanning from simple to complex physiotherapy techniques, conservative treatments including steroidal and non-steroidal anti-inflammatory drugs, hyaluronic acid, polysulfated glycosaminoglycans, pentosan polysulfate, and polyacrylamides, to promising regenerative therapies such as hemoderivatives and stem cell-based therapies. Each therapeutic modality is scrutinized for its benefits, limitations, and potential synergistic actions to facilitate their most effective application for the intended healing/regeneration of the injured tissue/organ and subsequent patient recovery. While stem cell-based therapies have emerged as particularly promising for equine musculoskeletal injuries, a multidisciplinary approach is underscored throughout the discussion, emphasizing the importance of considering various therapeutic modalities in tandem.

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Intra-articular 2.5% polyacrylamide hydrogel, a new concept in the medication of equine osteoarthritis: A review

Tnibar

2022

Journal of Equine Veterinary Science

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An assessment of the effectiveness of hyaluronic acid and polyacrylamide hydrogel in horses with osteoarthritis: Systematic review and network meta-analysis

Cited by 5 publications

References 45 publications

Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review

Intra-articular 2.5% polyacrylamide hydrogel, a new concept in the medication of equine osteoarthritis: A review

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