An Assessment of the Effect of Haematocrit on the Hemocue Blood Glucose Analyser

Wiener, K

doi:10.1177/000456329303000116

Cited by 40 publications

(21 citation statements)

References 4 publications

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“…Although evaluation of the trueness of meters and strips was not the main objective of this study, it is interesting to note that only the HemoCue results did not show any deviation from the results of the conventional reference method, a finding that is in agreement with some studies (18 -20 ) but in contrast to others (21)(22)(23). For one of the instruments, the Accu-Chek Sensor, one lot showed a significantly larger deviation from the reference method than the other two lots.…”

Section: Discussionsupporting

confidence: 88%

Between-Lot Variation in External Quality Assessment of Glucose: Clinical Importance and Effect on Participant Performance Evaluation

et al. 2005

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Background: External quality assessment schemes (EQAS) are conducted to evaluate user performance (participant assessment) and to assess different methods and instruments (method assessment). The quality of control materials is crucial to achieving these goals. Inconsistencies in between-lot variations detected by use of different control and sample materials may affect EQAS outcomes. Methods: For the Accu-Chek Sensor, Precision Xtra, Ascensia Elite, and HemoCue 201 glucometers, 3 different lots of glucose strips were used with each instrument. Method assessment results from analysis of capillary blood and 3 control materials were used to calculate between-lot differences. A simulation study was performed to evaluate the effect of between-lot variation on participant assessment results. Results: With the Precision Xtra, the results obtained with EQA control material mirrored those obtained with capillary blood, but for the other instruments, we found between-lot differences of as much as 1.3 mmol/L, which were substantially greater than those found with capillary blood and of clinical importance at decision limits. The simulation study showed an effect on participant assessment results related to the target values, with the percentage of poor results decreasing (38%, 10%, and 4%) with the use of common, method-specific, and lot-specific target values, respectively. Conclusions: Between-lot variation may influence participant EQA results for participant and method assessments. The clinical relevance of between-lot variation

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Section: Discussionsupporting

confidence: 88%

Between-Lot Variation in External Quality Assessment of Glucose: Clinical Importance and Effect on Participant Performance Evaluation

et al. 2005

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“…Similar findings of higher blood glucose values using the HemoCue system in comparison with the YSI values have been reported in an adult population. 28 While this has been thought to be due to a more complete lysis of neonatal erythrocytes by the saponin,"8 we found this tendency even in comparison with the hexokinase method (in which proteins are denatured by perchloric acid), and the plasma method on Ektachem.…”

Section: Discussionmentioning

confidence: 56%

Measuring blood glucose in neonatal units: how does hemocue compare?

Deshpande

Matthews

Platt

1996

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…This has been further complicated by the fact that the device has been used a number of times for neonatal hypoglycemic samples, which are from a very specific patient group, different from adults in several ways. Although one study (46) showed no marked effect of hematocrit on glucose measurements presumably, although not mentioned specifically, in adult blood, it is possible that either hematocrit or other factors in neonatal blood have influenced the results (47). When discussing the data provided by studies on blood glucose measurement, we believe that the accuracy and variability of the reference method used should also be taken into account, as there is no generally accepted gold standard, except perhaps for isotope dilution mass spectrometry.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the accuracy of the hemocue glucose analyzer with the Yellow Springs Instrument glucose oxidase analyzer, particularly in hypoglycemia

et al. 2005

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Objective: We aimed to assess the accuracy of the HemoCue Beta-glucose analyzer (HemoCue) and its correlation with the Yellow Springs Instrument (YSI 2300 STAT; YSI) glucose oxidase analyzer, in particular for hypoglycemic values. Design and methods: Samples were taken from 24 volunteers during hyperinsulinemic glucose clamp studies. Glucose concentrations were determined immediately with the HemoCue in whole blood and with the YSI in plasma from the same sample. After correction for the difference between whole blood and plasma, the paired plasma glucose concentrations were analyzed with various statistical methods.Results: A total of 500 paired glucose values were obtained, 209 of which were in the hypoglycemic range. Mean^S.E. values were 4.85^0.004 mmol/l for the HemoCue (range 1.87 -16.17) and 4.81^0.004 mmol/l for the YSI (range 1.88 -15.00; P ¼ 0.80). In the hypoglycemic region, values were 3.26^0.004 mmol/l for the HemoCue (range 1.87 -5.17) and 3.22^0.003 mmol/l for the YSI (range 1.88 -4.20; P ¼ 0.59). Regression analyses were HemoCue ¼ 1.019(YSI) 2 0.0577 mmol/l, with r ¼ 0.9787 for all values; for hypoglycemic values the HemoCue ¼ 1.1169(YSI) 2 0.3393 mmol/l, with r ¼ 0.8798. Using Altman's residual plot, the difference was 0.03^0.0009 mmol/l, with 18 (3.6%) paired values outside the 95% limits of agreement (20.82 to 0.89 mmol/l). In the hypoglycemic range, the difference was 0.04^0.001 mmol/l, with six (2.9%) values outside the 95% limits of agreement (2 0.71 to 0.79 mmol/l). In error grid analysis, one value was in zone D (0.2%) and five values (1%) were in zone B; 98.8% were within zone A. Conclusions: Determination of glucose with the HemoCue system had very good correlation with the YSI system in a broad range of glycemia and also for hypoglycemic values. We believe that these methods can be used interchangeably for research and clinical purposes in adults.European Journal of Endocrinology 153 275-281

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An Assessment of the Effect of Haematocrit on the Hemocue Blood Glucose Analyser

Cited by 40 publications

References 4 publications

Between-Lot Variation in External Quality Assessment of Glucose: Clinical Importance and Effect on Participant Performance Evaluation

Between-Lot Variation in External Quality Assessment of Glucose: Clinical Importance and Effect on Participant Performance Evaluation

Measuring blood glucose in neonatal units: how does hemocue compare?

Comparison of the accuracy of the hemocue glucose analyzer with the Yellow Springs Instrument glucose oxidase analyzer, particularly in hypoglycemia

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