Nuclear powered spacecraft will enable missions well beyond the capabilities of current chemical, radioisotope thermoelectric generator and solar technologies. The use of fi ssion reactors for space applications has been studied for over 50 years. Structural material performance has often limited the potential performance of space reactors. Space fi ssion reactors are an extremely harsh environment for structural materials with high temperatures, high neutron fi elds, potential contact with liquid metals, and the need for up to 15-20 year reliability with no inspection or preventative maintenance. Many different structural materials have been proposed. While all of those proposed meet many of the requirements for space reactor service, none satisfy all of them. However, continued development and testing may resolve these issues and provide qualifi ed materials for fi ssion reactors for space power.