An assessment of mast cells and myofibroblasts in denture‐induced fibrous hyperplasia

Kiuchi, Misa; Yamamura, Takashi; Okudera, Michisato; Vongsa, Souksavanh; Ishigami, Tomohiko; Igarashi, Takashi; Warnakulasuriya, Saman; Komiyama, Kanki

doi:10.1111/jop.12072

Cited by 7 publications

(4 citation statements)

References 34 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this cell population was also seen in areas of fibrosis even in the absence of inflammation. This finding has also been reported in other studies on FH lesions [30][31][32]. The presence of MCs in areas of fibrosis may be attributed to the fact that their granules are rich in proteases, including tryptase [4].…”

Section: Discussionsupporting

confidence: 86%

“…There is consensus among studies regarding the distribution of MCs around blood vessels [1,11,15] and this was confirmed in the present study. Mast cells were frequently observed in areas of ulceration and inflammation, as reported in previous studies [11,15] including reactive lesions [31][32][33]. However, this cell population was also seen in areas of fibrosis even in the absence of inflammation.…”

Section: Discussionsupporting

confidence: 74%

See 1 more Smart Citation

Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study

Ferreira

Xavier

Freitas

et al. 2016

Pathology - Research and Practice

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 74%

Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study

Ferreira

Xavier

Freitas

et al. 2016

Pathology - Research and Practice

View full text Add to dashboard Cite

“…Even though the oral mucosa heals with minimal fibrosis, the formation of a scar cannot be ruled out [15]. Further evidence exists for denture-induced fibrous hyperplasia [16] and dental materials can also cause fibrosis [17]. Clinical scenarios like these have prompted research seeking to uncover the molecular link between cell damage, tissue regeneration, and scar-like repair.…”

Section: Introductionmentioning

confidence: 99%

Gingival Fibroblasts Are Sensitive to Oral Cell Lysates Indicated by Their IL11 Expression

Panahipour,

Abbasabadi,

Gruber

2023

Bioengineering

View full text Add to dashboard Cite

Damaged cells that appear as a consequence of invasive dental procedures or in response to dental materials are supposed to release damage-associated signals. These damage-associated signals not only support tissue regeneration but might also contribute to unwanted fibrosis. The aim of this study was to identify a molecular target that reflects how fibroblasts respond to necrotic oral tissue cells. To simulate the cell damage, we prepared necrotic cell lysates by sonication of the osteocytic cell line IDG-SW3 and exposed them to gingival fibroblasts. RNAseq revealed a moderate increase in IL11 expression in the gingival fibroblasts, a pleiotropic cytokine involved in fibrosis and inflammation, and also in regeneration following trauma. Necrotic lysates of the human squamous carcinoma cell lines HSC2 and TR146, as well as of gingival fibroblasts, however, caused a robust increase in IL11 expression in the gingival fibroblasts. Consistently, immunoassay revealed significantly increased IL11 levels in the gingival fibroblasts when exposed to the respective lysates. Considering that IL11 is a TGF-β target gene, IL11 expression was partially blocked by SB431542, a TGF-β receptor type I kinase inhibitor. Moreover, lysates from the HSC2, TR146, and gingival fibroblasts caused a moderate smad2/3 nuclear translocation in the gingival fibroblasts. Taken together and based on IL11 expression, our findings show that fibroblasts are sensitive to damaged oral tissue cells.

show abstract

“…Inflammatory fibrous hyperplasia (IFH) is one of the most common injuries in clinical routines [10]. Its occurrence is linked to chronic trauma of low intensity in patients with complete dentures [11] and is a lesion with no potential for malignant transformation. However, it does require surgical removal, histopathological diagnostic confirmation and correct clinical management.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of inflammatory processes by FTIR spectroscopy

Rodrigues

Carvalho

Bonnier

et al. 2018

Journal of Medical Engineering & Technology

View full text Add to dashboard Cite

Fourier transform infrared (FTIR) spectroscopy is a powerful diagnosis technique and has been used to identify patterns of molecular changes based on vibration modes. The objective of this study was to evaluate inflammatory fibrous hyperplasia (IFH) lesions and oral normal mucosa (NM) initially with histopathological exam and then using micro-FTIR spectroscopy to analyse the samples. Eleven IFH and 11 NM samples were analysed at five different points to cover the largest area possible by the micro-FTIR technique. Bands were observed between 970 and 1743 cm which corresponded to different structural components like collagen, lipids, fatty acids, proteins and amino acids. Spectral bands were more intense mostly for IFH lesions, including collagen bands, which are an important component of inflammatory fibrous hyperplasia. This study demonstrated that differentiation in the inflammatory tissue was observed in FTIR spectral differences, in terms of biochemical composition.

show abstract

An assessment of mast cells and myofibroblasts in denture‐induced fibrous hyperplasia

Abstract: These results are the first to show that mast cells and myofibroblasts can be detected in DIFH, indicating important roles of these cells in the pathogenesis of this lesion.

Cited by 7 publications

References 34 publications

Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study

Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study

Gingival Fibroblasts Are Sensitive to Oral Cell Lysates Indicated by Their IL11 Expression

Evaluation of inflammatory processes by FTIR spectroscopy

Contact Info

Product

Resources

About