An Assessment of Gastric Acid Secretory Response with `Maximal' Augmented Histamine Stimulation in Children with Peptic Ulcer

Op, Ghai; Singh, Meharban; Walia, B. N. S.; Gadekar, N. G.

doi:10.1136/adc.40.209.77

Cited by 43 publications

(14 citation statements)

References 12 publications

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“…Ghai, Singh, Walia, and Gadekar (1965) performed augmented histamine test meals on duodenal ulcer cases and on a control group of normal children; there was no significant difference in basal acid output between the two (53 9%)…”

Section: Discussionmentioning

confidence: 99%

“…At the time of the augmented histamine test only 4 of the 19 ulcer patients had had a prolonged spell of freedom from ulcer symptoms, so that any attempt to correlate maximal acid output with ulcer activity would be misleading. It is of interest that in the control group studied by Ghai et al (1965) maximal acid output in the control group was 2-02 mEq/hr./10 kg. wt.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Duodenal ulcer in childhood. A study of predisposing factors.

Habbick¹,

Melrose²,

Grant³

1968

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Duodenal ulcer in childhood. A study of predisposing factors.

Habbick¹,

Melrose²,

Grant³

1968

Archives of Disease in Childhood

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“…Only recently the principles for the augmented histamine test (careful aspiration and protection with antihistamine drugs so that large doses of histamine can be given) have been applied t o the study of gastric secretion in childhood (Ghai, Singh, Walia & Gadekar 1965).…”

mentioning

confidence: 99%

Gastric Secretion of Pepsin in Early Childhood

Rødbro¹,

Krasilnikoff²,

Bitsch³

1967

Scandinavian Journal of Gastroenterology

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R~D B R O , P., KRASILNIKOFF, P. A. & BITSCH, VIBEKE. Gastric Secretion of Pepsin in Early Childhood. Scand. J. Gastroent. 2, 257-260, 1967. In 18 children, 9-30 months of age, without gastrointestinal disorders, the gastric secretion of pepsin was studied before and after augmented histamine stimulation. Histamine resulted in a slight increase of the hourly pepsin output, which, however, was not significantly higher than in the basal hour. The basal pepsin output was significantly correlated to age and body surface area, while the stimulated pepsin output was not significantly correlated to age, body-weight, body surface area, basal pepsin output, or stimulated acid output. & BITSCH, V. (1966) Gastric secretion in early childhood. Lancet 11.730-731.

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“…The simplest hypothesis is that maximum acid output (Kay, 1953) as a function of the parietal cell mass of the stomach (Card and Marks, 1960) is a function of body weight, and significant correlations have been found between maximum acid output and body weight in animals, such as the rat (Shay, Sun, and Gruenstein, 1954) and the dog (Baron, un-published data), as well as the human child (Ghai, Singh, Walia, and Gadekar, 1965) and infant (Rodbro, Krasilnikoff, and Christiansen, 1967), with no differences between the sexes.…”

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confidence: 99%

Lean body mass, gastric acid, and peptic ulcer

Baron¹

1969

Gut

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SUMMARY Peak acid outputs in normal subjects and patients with duodenal and gastric ulcer were significantly (and similarly) correlated with body weight and calculated lean body mass.Expression of measurements of peak acid output as a function of body weight or lean body mass lessened but did not abolish the significance of the situation that men with no dyspepsia or gastric ulcer secreted more acid than women; the significant sex difference in duodenal ulcer was, however, abolished.Data for peak acid output have been tabulated, not only as m-equiv/hr but also as g-equiv/kg body weight/hr and g-equiv/kg lean body mass/hr. On the basis of the present data no change is suggested in the current expression of peak acid output as m-equiv/hr since expression of acid output as a function of body weight or lean body mass improves neither the variability nor the diagnostic discrimination of measurement of peak acid output.There have been many attempts to relate gastric secretion to different measurements of body build. The simplest hypothesis is that maximum acid output (Kay, 1953) as a function of the parietal cell mass of the stomach (Card and Marks, 1960) is a function of body weight, and significant correlations have been found between maximum acid output and body weight in animals, such as the rat (Shay, Sun, and Gruenstein, 1954) and the dog (Baron, unpublished data), as well as the human child (Ghai, Singh, Walia, and Gadekar, 1965) and infant (Rodbro, Krasilnikoff, and Christiansen, 1967), with no differences between the sexes.

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An Assessment of Gastric Acid Secretory Response with `Maximal' Augmented Histamine Stimulation in Children with Peptic Ulcer

Cited by 43 publications

References 12 publications

Duodenal ulcer in childhood. A study of predisposing factors.

Duodenal ulcer in childhood. A study of predisposing factors.

Gastric Secretion of Pepsin in Early Childhood

Lean body mass, gastric acid, and peptic ulcer

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