An assessment of EGFR and HER2 inhibitors with structure activity relationship of fused pyrimidine derivatives for breast cancer: a brief review

Dhiwar, Prasad Sanjay; Matada, Gurubasavaraja Swamy Purawarga; Pal, Rohit; Singh, Ekta; Ghara, Abhishek; Maji, Lalmohan; Sengupta, Sindhuja; Andhale, Ganesh Sakharam

doi:10.1080/07391102.2023.2204351

Cited by 6 publications

(2 citation statements)

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“…The two nitrogen atoms in pyrimidine are situated at positions 1 and 3 in the ring. [88] Pyrimidine has a wide range of pharmacological activities, making it the most significant Ncontaining heterocyclic molecule. [89] Gaber et al, reported the biological potential of 1H-pyrazolo [3,4-d] pyrimidine analogues as EGFR WT and EGFR T790M inhibitors.…”

Section: Pyrimidinementioning

confidence: 99%

“…Pyrimidine belongs to N ‐containing heterocyclic organic compounds. The two nitrogen atoms in pyrimidine are situated at positions 1 and 3 in the ring [88] . Pyrimidine has a wide range of pharmacological activities, making it the most significant N‐ containing heterocyclic molecule [89] .…”

Section: Recent Development Of Different Nitrogen Containing Derivati...mentioning

confidence: 99%

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Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships

Pal¹,

Teli²,

Matada³

et al. 2023

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proved to be the magical weapon in designed and discovery of synthetic molecules as they acquired comprehensive range of pharmacological properties. In recent year (2018-2022) Nheterocyclic derivatives were uncovered as the potential EGFR TKIs. The present review summarised the research progress of EGFR TKIs to dazed the limitations of currently accessible drugs by consecrating, anatomy, mutation of EGFR, and its role in different types of cancer. The review highlights the medicinal chemistry prospective emphasising about the designing strategies, docking studies, biological evaluation, selectivity and structural activity relationship of N-heterocyclic compounds. Our review will support the medicinal chemists in direction for the development of novel N-heterocyclic based EGFR TKIs.

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Section: Pyrimidinementioning

confidence: 99%

Section: Recent Development Of Different Nitrogen Containing Derivati...mentioning

confidence: 99%