An Assessment of Changes in Liver Function During Normal Pregnancy—using a Modified Bromsulphthalein Test

Tindall, V. R.; Beazley, J. M.

doi:10.1111/j.1471-0528.1965.tb00090.x

Cited by 40 publications

(26 citation statements)

References 17 publications

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“…Estrone had no significant effect on the hepatic content of albumin, Na', K+, or mannitol, nor were there discernible relations between any of these measurements and bile flow. By using the plasma equivalent space occupied by albumin as a measure of extracellular fluid in the liver, the ratio of sucrose concentrations in intracellular water and plasma were estimated from the relation, [5] bile flow biliary sucrose concentration in rats given es-lie between the space for albumin and that for sodium. trone was more than twice the estimated concentration If sodium is used in the, present instance, the effect is within liver cells.…”

Section: Methodsmentioning

confidence: 99%

“…Sporadic occurrence of recurrent jaundice and/or pruritus in the last trimester of pregnancy (1)(2)(3), abnormal removal of sulfobromophthalein (BSP) during otherwise uncomplicated pregnancy (4,5), and the predisposition of multiparous women to form gallstones all point to a possible association between high levels of circulating estrogen and altered bile formation. Scattered reports (6)(7)(8)(9) of cholestasis following the use of oral contraceptives have heightened this suspicion as have recent suggestions (10)(11)(12), that impaired hepatic excretion in the newborn may reflect, at least in part, a deleterious effect of maternal estrogen on the fetus.…”

Section: Introductionmentioning

confidence: 99%

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The effect of estrogen on bile formation in the rat

Forker¹

1969

J. Clin. Invest.

155

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of estrogen on bile formation in the rat

Forker¹

1969

J. Clin. Invest.

155

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“…20,21 A redução da depuração hepática em presença de gravidez não pode ser explicada apenas com base nos achados do presente trabalho. Tindall & Beazley (1965), estudando as funções do fígado na gravidez, encontraram uma relação entre o elevado nível de estrogênio circulante e as alterações funcionais desse órgão. 29 Hiperbilirrubinemia, desglicogenização, aumento do teor de aminoácidos e a hepatomegalia também já foram descritos durante o período gestacional.…”

Section: Discussionunclassified

“…Tindall & Beazley (1965), estudando as funções do fígado na gravidez, encontraram uma relação entre o elevado nível de estrogênio circulante e as alterações funcionais desse órgão. 29 Hiperbilirrubinemia, desglicogenização, aumento do teor de aminoácidos e a hepatomegalia também já foram descritos durante o período gestacional. 30 O baço é responsável por 25% a 30% da depuração sangüínea, seguido pelos pulmões -5% a 10%.…”

Section: Discussionunclassified

Atividade fagocitária do sistema mononuclear fagocitário na gravidez

Vasconcellos¹,

Sabino

Petroianu³

et al. 2003

Rev. Bras. Hematol. Hemoter.

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Effect of Pregnancy on the Excretion of Sulphobromophthalein in Bile

Shaw¹,

Heath²

1972

Aust. Jnl. Of Bio. Sci.

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A decreased plasma clearance of sulphobromophthalein (BSP) is often observed during the latter half of normal human pregnancy (Tindall and Beazley 1965). It also occurs during the ingestion of oral contraceptives (Roman and Hecker 1968) and after treatment with oestrogens at doses similar to those produced daily in late pregnancy (Kappas 1968). A reduction in bile flow has been described after oestrogen treatment in rats (Javitt and Harkavy 1969;Forker 1969;Kreek et al. 1967), but no attempts appear to have been made to associate changes in bile flow rate with alterations in BSP excretion.In this study, the effect of variations in the flow of bile on the excretion of BSP was assessed in pregnant and non-pregnant rabbits. Materials and MethodsSeven 4-month-old New Zealand white rabbits weighing 2·7-3· S kg were obtained at the time of nesting, which was within 2-3 days of term. Fourteen virgin rabbits of the same age and weight acted as controls. Experiments were conducted alternately with pregnant rabbits and controls and both groups of animals were fasted for at least IS hr before operation.Rabbits were anaesthetized with pentobarbitone sodium (i.v. 25 mg/kg body weight). In each rabbit, the cystic duct was ligated and a polyethylene catheter (1·50 mm o.d.), 15 cm in length, was inserted into the common bile duct at the hilus of the liver. Initial rates of bile flow were determined for both pregnant and control rabbits immediately after cannulation. Sulphobromophthalein (Bromthalein, E. Merck, Darmstadt, Germany; 50 mg/ml) was injected into the marginal ear vein at the dose of O· 75, 2· 0, and 5·0 mg/kg in non.pregnant rabbits and 2·0 and 5·0 mg/kg in pregnant rabbits, and sequential samples of bile were collected into tared containers until the samples were free from the dye. Each rabbit was used for up to three separate determinations of BSP excretion rate. In order to estimate the excretion rate of BSP at low rates of bile flow in control rabbits, bile was allowed to drain from all control rabbits for a period of 4 hr. After this time, bile flow rate had declined significantly due to interruption of the enterohepatic circulation of bile salts.The concentrations and excretion rates of BSP were estimated after dilution of O· 07 -ml portions of bile with 3 ml of O·OSN NaOH; this achieved concentrations of BSP that could be measured at 585 nm in a Beckman DU 4700 spectrophotometer. Since the excretory rates of BSP into bile increased to a peak about 12 min after injection, then gradually decreased with time, the excretory rate for a particular dose of dye was taken arbitrarily as the product of bile * Manuscript

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An Assessment of Changes in Liver Function During Normal Pregnancy—using a Modified Bromsulphthalein Test

Cited by 40 publications

References 17 publications

The effect of estrogen on bile formation in the rat

The effect of estrogen on bile formation in the rat

Atividade fagocitária do sistema mononuclear fagocitário na gravidez

Effect of Pregnancy on the Excretion of Sulphobromophthalein in Bile

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