An Assessment of Cataract Severity Based on Antioxidant Status and Ascorbic Acid Levels in Aqueous Humor

Tsao, Yu‐Ting; Wu, Wei‐Chi; Chen, Kuan‐Jen; Liu, Chunfu; Hsueh, Yi‐Jen; Cheng, Chao‐Min; Chen, Hung-Chi

doi:10.3390/antiox11020397

Cited by 9 publications

(9 citation statements)

References 53 publications

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“… 53 Few reports have mentioned changes in the antioxidant capacity of aqueous humor, with which the lens is in direct contact. Tsao et al 27 reported that ascorbic acid and TAC levels in the aqueous humor have a significant negative correlation with cataract severity, which is consistent with our results.…”

Section: Discussionsupporting

confidence: 93%

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Chronic Antioxidant Capacity Loss in Anterior Chamber Environment After Iridectomy

Arimura

Iwasaki

Neo

et al. 2023

Trans. Vis. Sci. Tech.

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Purpose To compare the ascorbic acid concentration and total antioxidant capacity in the aqueous humor of pigmented Rex rabbits after sham operation (control), iridectomy, and trabeculectomy. Methods Pigmented Rex rabbits were divided into control, iridectomy, and trabeculectomy groups and followed up for 12 months after surgery. Ascorbic acid concentration and total antioxidant capacity in the aqueous humor, intraocular pressure, and the occurrence of cataracts were examined in each group. Results The ascorbic acid concentration and total antioxidant capacity after iridectomy and trabeculectomy were significantly lower at one week and at one, six, and 12 months after operation than those in the control group ( P ≤ 0.03). Ascorbic acid concentration was positively and significantly correlated with total antioxidant capacity in the aqueous humor ( P < 0.01). Compared to the control and the iridectomy groups, intraocular pressure in the trabeculectomy group was significantly lower at one week and at one and six months after surgery (one week: P < 0.01 and P < 0.01, respectively; one month: P < 0.01 and P = 0.03, respectively; six months: P = 0.03). Histological findings in the iridectomy and trabeculectomy groups included the appearance of vacuoles in the lens at six and 12 months after surgery. Conclusions Iridectomy causes a sustained decrease in ascorbic acid concentration, followed by a long-term decrease in the total antioxidant capacity within the aqueous humor. Translational Relevance The animal model possibly predicts the vulnerability focusing on the antioxidant level in the anterior chamber environment after trabeculectomy and iridectomy per se in clinical settings.

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Section: Discussionsupporting

confidence: 93%

“… 26 Ascorbic acid is expected to account for a high proportion of TAC in aqueous humor. 27 Therefore we aimed to determine whether iridectomy per se would alter the antioxidant environment in the aqueous humor by measuring ascorbic acid concentration and total antioxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

Chronic Antioxidant Capacity Loss in Anterior Chamber Environment After Iridectomy

Arimura

Iwasaki

Neo

et al. 2023

Trans. Vis. Sci. Tech.

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“…It has been widely shown that sunlight, as well as incandescent lamps, can represent a risk factor for the health of the eye and especially for the retina. To date, the replacement of incandescent light with a compact fluorescent lamps (CFLs) or light emitting diodes (leds), is particularly diffused and these low energy devices have increased the possibility of phototoxic eye damage [223,224]. On the other hand, oxidative stress, which occurs in case of an overproduction of ROS or a failure of cellular buffering mechanisms, is able to alter the health of the eye by oxidation of biological macromolecules and an imbalance at the molecular and cellular level [225,226].…”

Section: Discussionmentioning

confidence: 99%

Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection

Maiuolo¹,

Bulotta²,

Oppedisano³

et al. 2022

Preprint

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Eye health is crucial and the onset of diseases can reduce vision and affect the quality of life of patients. The main causes of progressive and irreversible vision loss include various pathologies such as cataracts, ocular atrophy, corneal opacity, age-related macular degeneration, uncorrected refractive error, posterior capsular opacification, uveitis, glaucoma, diabetic retinopathy, retinal detachment, undetermined disease and other disorders involving oxidative stress and inflammation. The eyes are constantly exposed to the external environment and, for this reason, must be protected from damage from the outside. Many drugs, including cortisonics and antinflammatory drugs have widely been used to counteract eye disorders. However, recent advances have been obtained via supplementation of patients with natural antioxidants and nutraceuticals. In particular, evidence has been accumulated that polyphenols (mostly deriving from Citrus Bergamia) represent a reliable source of antioxidants able to counteract oxidative stress accompanying early stages of eye diseases. Luteolin, in particular, has been found to protect foto-receptors thereby improving vision in many disease states. Moreover, a consistent anti-inflammatory response was found to occur when curcumin is used alone or in combination with other nutraceuticals. On the other hand, CoQ10 has been demonstrated to produce consistent effect in reducing ocular pressure thereby leding to protection in patients undergoing glaucoma. Finally, both grape seed extract rich in anthocyanosides and polynsatured fatty acids (PUFAs) seem to contribute in the prevention of retinal disorders. Thus, combination of nutraceuticals and anti-oxidants may represent the right solution for a multiaction activity in eye protection to be associated to current drug therapies, and this will be of potential interest in early stages of eye disorders.

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“…For this very reason, it would be advisable to use these protective mixtures from the age of 40 years onwards. This can be explained by the need to not already have accumulated excessive amounts of ROS related to aging, to avoid undergoing demanding pharmacological treatments that may affect oxidative stress and have not been subjected to an excess of adverse environmental factors [ 274 , 275 ].…”

Section: Antioxidant Mixtures To Protect/reduce Eye Diseasesmentioning

confidence: 99%

Potential Properties of Natural Nutraceuticals and Antioxidants in Age-Related Eye Disorders

Maiuolo

Bulotta

Oppedisano

et al. 2022

Life

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Eye health is crucial, and the onset of diseases can reduce vision and affect the quality of life of patients. The main causes of progressive and irreversible vision loss include various pathologies, such as cataracts, ocular atrophy, corneal opacity, age-related macular degeneration, uncorrected refractive error, posterior capsular opacification, uveitis, glaucoma, diabetic retinopathy, retinal detachment, undetermined disease and other disorders involving oxidative stress and inflammation. The eyes are constantly exposed to the external environment and, for this reason, must be protected from damage from the outside. Many drugs, including cortisonics and antinflammatory drugs have widely been used to counteract eye disorders. However, recent advances have been obtained via supplementation with natural antioxidants and nutraceuticals for patients. In particular, evidence has accumulated that polyphenols (mostly deriving from Citrus Bergamia) represent a reliable source of antioxidants able to counteract oxidative stress accompanying early stages of eye diseases. Luteolin in particular has been found to protect photoreceptors, thereby improving vision in many disease states. Moreover, a consistent anti-inflammatory response was found to occur when curcumin is used alone or in combination with other nutraceuticals. Additionally, Coenzyme Q10 has been demonstrated to produce a consistent effect in reducing ocular pressure, thereby leading to protection in patients undergoing glaucoma. Finally, both grape seed extract, rich in anthocyanosides, and polynsatured fatty acids seem to contribute to the prevention of retinal disorders. Thus, a combination of nutraceuticals and antioxidants may represent the right solution for a multi-action activity in eye protection, in association with current drug therapies, and this will be of potential interest in early stages of eye disorders.

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An Assessment of Cataract Severity Based on Antioxidant Status and Ascorbic Acid Levels in Aqueous Humor

Cited by 9 publications

References 53 publications

Chronic Antioxidant Capacity Loss in Anterior Chamber Environment After Iridectomy

Chronic Antioxidant Capacity Loss in Anterior Chamber Environment After Iridectomy

Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection

Potential Properties of Natural Nutraceuticals and Antioxidants in Age-Related Eye Disorders

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