An assessment of beta‐adrenoceptor blockade in man by prizidilol hydrochloride.

Pitcher, DW; Curry, PV; Trounce, J R

doi:10.1111/j.1365-2125.1982.tb01441.x

Cited by 6 publications

(2 citation statements)

References 4 publications

(4 reference statements)

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“…Oral administration of prizidilol hydrochloride at a dose of 5 mg/kg has significantly lowered systemic blood pressure without increasing standing heart rate (Bell et al, 1980). ,3-adrenoceptor curbing of isoprenaline induced rises in heart rate has been demonstrated following administration of a single oral dose of 200 mg prizidilol hydrochloride (Pitcher, Curry & Trounce, 1980). In contrast to these observations, intravenous infusion of prizidilol hydrochloride led to a significant rise in resting pulse rate.…”

Section: Discussionmentioning

confidence: 95%

Cardiovascular effects in man of intravenous prizidilol hydrochloride (SK&F 92657); a new antihypertensive agent.

Edmonstone¹,

Manghani²,

Bell³

et al. 1981

Brit J Clinical Pharma

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1 Cardiovascular responses to intravenous prizidilol hydrochloride (SK&F 92657) 0.86 mg/kg were studied in eight supine resting healthy volunteers. Five subjects were slow and the remaining three were fast acetylators of sulphamethazine. Compared with pre-infusion values, mean resting systolic and diastolic blood pressures were significantly reduced, while mean resting pulse rate was significantly increased at 30 min after the start of the twenty minute infusion. 2 During the 6 h study period the lowest mean ± s.e. mean systolic blood pressure (108.8 + 1.7) was recorded 30 min after the start of the infusion. This represented a mean reduction of 5.2 mmHg. Reductions in mean diastolic blood pressure were greater and of longer duration, the lowest mean value (44.8 + 2.0 mmHg) being recorded 3.5 h after the start of the infusion and representing a reduction of 18.5 mmHg from the pre-dosing value. At 6 h after the start of the infusion mean diastolic blood pressure was still significantly reduced (by 15.3 mmHg). 3 The maximum mean + s.e. mean resting pulse rate (79.3 ± 4.4 beats/min) occurred 3 h after the start of the infusion, an increase of 23.0 beats/min over the pre-infusion value. At the end of the study the pulse rate was still significantly raised (by 17.7 beats/min). 4 The left ventricular ejection fraction, evaluated in five subjects, 45 min after the start of the infusion, was not altered by prizidilol hydrochloride, but the left ventricular area decreased significantly. 5 Intravenous prizidilol hydrochloride decreases resting blood pressure and left ventricular area, increases pulse rate and has virtually no effect on left ventricular ejection fraction.

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Section: Discussionmentioning

confidence: 95%

Cardiovascular effects in man of intravenous prizidilol hydrochloride (SK&F 92657); a new antihypertensive agent.

Edmonstone¹,

Manghani²,

Bell³

et al. 1981

Brit J Clinical Pharma

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“…Similar observations were made by Steiner et al (1981) and Bell et al (1979), although the latter demonstrated a significantly increased supine heart rate after 400 mg oral prizidilol. However, Pitcher et al (1982) heart rate after 200 mg oral prizidilol and concluded that this dose caused /3-adrenoceptor antagonism without the vasodilatation apparent at higher doses. Prizidilol therefore caused a significant reduction in blood pressure associated with an increased cardiac output and an unchanged heart rate.…”

Section: Discussionmentioning

confidence: 98%

Pulmonary effects in man of oral prizidilol hydrochloride (SK&F 92657), a new antihypertensive agent.

Edmondstone¹,

Waller²,

Manghani³

et al. 1983

Brit J Clinical Pharma

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Hertfordshire1 The effects on heart rate, blood pressure and pulmonary function of single oral doses of prizidilol hydrochloride (400 mg SK&F 92657) and propranolol (40 mg) were compared with placebo in nine healthy volunteers, in a double blind crossover study. 2 Prizidilol had no effect on heart rate while propranolol caused a significant reduction compared with placebo. Diastolic blood pressure was lowered to the same extent by both prizidilol and propranolol.3 Propranolol significantly reduced the forced expiratory volume in 1 second (FEVy), forced vital capacity (FVC) and the maximal expiratory flow at 50% vital capacity (MEF 50). Prizidilol had no effect on flow-volume loop parameters. 4 Effective pulmonary blood flow was not altered by propranolol, but it was significantly increased by prizidilol. 5 Oral prizidilol exerts its hypotensive effect by vasodilatation without reflex tachycardia. It does not cause airways obstruction in healthy subjects.

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Neue therapeutische Ansätze zur Behandlung der arteriellen Hypertonie

Borchard¹

1984

Arterielle Hypertonie

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An assessment of beta‐adrenoceptor blockade in man by prizidilol hydrochloride.

Cited by 6 publications

References 4 publications

Cardiovascular effects in man of intravenous prizidilol hydrochloride (SK&F 92657); a new antihypertensive agent.

Cardiovascular effects in man of intravenous prizidilol hydrochloride (SK&F 92657); a new antihypertensive agent.

Pulmonary effects in man of oral prizidilol hydrochloride (SK&F 92657), a new antihypertensive agent.

Neue therapeutische Ansätze zur Behandlung der arteriellen Hypertonie

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