An assessment of animal models for testing the effect of photochemical oxidants on pulmonary susceptibility to bacterial infection

Goldstein, Elliot

doi:10.1080/15287398409530507

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…The experimental design used in this study differs from the typical "infectivity model," which is a standard design used to test the effects of airborne pollutants on the respiratory system (10). The usual experimental protocol is to expose animals to an oxidant for a period of time, often at higher concentrations than those experienced by humans, and then to challenge them with aerosolized bacteria (8,9). The experimental design used in this study was different, in that the mice were inoculated with U. urealyticum prior to the administration of oxygen, a scenario similar to that in a INFECT.…”

Section: Days After Inoculationmentioning

confidence: 99%

Hyperoxia potentiates Ureaplasma urealyticum pneumonia in newborn mice

et al. 1990

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The effect of continuous exposure to 80% oxygen on newborn mice with Ureaplasma urealyticum pneumonia was determined. Mice were inoculated intranasally with either U. urealyticum or sterile broth and then housed in either 80% oxygen or room air (21% oxygen). The mice were sacrificed at either 7 or 14 days after inoculation. Significantly more mice in the U. urealyticum group housed in 80% 02 than in the room airexposed group were culture positive 14 days after inoculation (P = 0.042), but no difference was found at 7 days. The presence of alveolar macrophages, neutrophils, and lymphocytes and alveolar wall thickness were determined. Overall, the group housed in 80% 02 and inoculated with U. urealyticum had severe pulmonary lesions at both time points, while the lesion severity in the room air-exposed group inoculated with U. urealyticum and the group housed in 80% 02 and inoculated with sterile broth was dependent on the time point. Mortality was significantly higher in the group housed in 80% 02 and inoculated with U. urealyticum than it was in all other groups (P < 0.001). Our results indicate that hyperoxia causes the persistence of U. urealyticum in the lungs of newborn mice, acutely potentiates the inflammatory response, and turns an otherwise selflimited pneumonia into a lethal disease.

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Section: Days After Inoculationmentioning

confidence: 99%

Hyperoxia potentiates Ureaplasma urealyticum pneumonia in newborn mice

et al. 1990

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“…24 Irritant gases, such as sulfur dioxide, nitrogen dioxide, and ozone, have been shown in animals to affect cilia function and mucociliary clearance adversely. [25][26][27] By affecting mucociliary clearance, these gases may predispose the host to increased respiratory infections, further increasing the risk of bronchitis. These effects are likely to follow a dose-response curve, and the effects may not be seen at lower levels of exposure.…”

Section: Pathophysiology Of Bronchitis and Irritant Exposurementioning

confidence: 99%

Occupational Bronchitis: A Marker for Irritant Exposure

Barnhart¹

1986

Semin Respir Crit Care Med

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“…This theme is expanded in the reviews of Goldstein (1984) and Gardner (1984). Certainly, many of the components of this defense system can be studied in humans as well as in animals.…”

Section: Introduction Philip a Brombergmentioning

confidence: 99%

Introduction

Bromberg¹

1984

Journal of Toxicology and Environmental Health

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An assessment of animal models for testing the effect of photochemical oxidants on pulmonary susceptibility to bacterial infection

Cited by 9 publications

References 25 publications

Hyperoxia potentiates Ureaplasma urealyticum pneumonia in newborn mice

Hyperoxia potentiates Ureaplasma urealyticum pneumonia in newborn mice

Occupational Bronchitis: A Marker for Irritant Exposure

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