An Assessment and Management of Plexiform Schwannoma of the Third Webspace in a Female: A Case Report

Abstract

Schwannoma is a rare benign soft tissue tumor that appears like a neuroma based on its specific location and clinical features. We report a case of a plexiform schwannoma in a middle-aged woman who had a painful bump located in the third webspace on the dorsum of her right foot for the last four years. Initially, the swelling was thought to be Morton's neuroma based on location and clinical feature findings. The mass was resected and was sent for histopathological examination, revealing a plexiform schwannoma, most likely developing from the cutaneous nerves on the dorsum of the foot. She reported improvement in her symptoms after complete and careful excision without any neurological deficit. Investigation of any subcutaneous foot swelling should be coupled with a histopathological examination for comprehensive management.

Rare giant schwannoma of superficial peroneal nerve on the dorsum of foot

“…Plexiform schwannoma is an entity distinct from conventional schwannoma. Very few cases in the foot and ankle region have been reported in literature 16–18. These tumours are typically found in the dermis and subcutaneous tissue.…”

Giant Plexiform Schwannoma on the Medial Aspect of the Left Thigh

“…PS is a rare neurogenic tumor first described by Harkin in 1978, and its etiology is not yet fully understood [ 3 ]. Most PSs are small, with a maximum diameter of approximately 2 cm, and originate from superficial nerves [ 4 ]. Schwannomas are intricately associated with several genetic disorders, notably schwannomatosis, neurofibromatosis type 2 (NF2), and Carney complex type 1 (CC1) [ 5 , 6 ].…”

“…Their occurrence in the extremities, particularly the thighs, is infrequent. It primarily affects individuals aged 30-40 years and typically appears as a solitary, slow-growing, painless nodule in the skin or subcutaneous tissue [ 4 ].…”