An Aroma Odyssey: The Promise of Volatile Fungal Metabolites in Biotechnology

Korn, Victoria L.; Padhi, Sally

doi:10.1007/978-3-030-29541-7_13

Cited by 2 publications

(1 citation statement)

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“…In some cases, it is not fully understood whether a particular fungal VOC is a direct product of fungal metabolism or rather a degradation product following osmotrophic, extracellular uptake of enzymatically degraded nutrients by fungal organisms [19]. Aside from their possible toxic potential, mVOCs have recently been discussed in relation to various biotechnological applications, and have been used, for instance, in agricultural plant disease control (mycofumigation), biofuel and mycodiesel production, in pharmaceutical approaches or as alternative for environmentally harmful pesticides [20][21][22][23].…”

Section: Microbial Volatile Organic Compounds (Mvocs)mentioning

confidence: 99%

In Vitro Systems for Toxicity Evaluation of Microbial Volatile Organic Compounds on Humans: Current Status and Trends

Cerimi

Jäckel

Meyer

et al. 2022

JoF

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Microbial volatile organic compounds (mVOC) are metabolic products and by-products of bacteria and fungi. They play an important role in the biosphere: They are responsible for inter- and intra-species communication and can positively or negatively affect growth in plants. But they can also cause discomfort and disease symptoms in humans. Although a link between mVOCs and respiratory health symptoms in humans has been demonstrated by numerous studies, standardized test systems for evaluating the toxicity of mVOCs are currently not available. Also, mVOCs are not considered systematically at regulatory level. We therefore performed a literature survey of existing in vitro exposure systems and lung models in order to summarize the state-of-the-art and discuss their suitability for understanding the potential toxic effects of mVOCs on human health. We present a review of submerged cultivation, air-liquid-interface (ALI), spheroids and organoids as well as multi-organ approaches and compare their advantages and disadvantages. Furthermore, we discuss the limitations of mVOC fingerprinting. However, given the most recent developments in the field, we expect that there will soon be adequate models of the human respiratory tract and its response to mVOCs.

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