An arm and a leg: A case of rheumatoid vasculitis and antiphospholipid antibody syndrome

Abstract

Rheumatoid vasculitis is a rare extra-articular complication of rheumatoid arthritis. The most common manifestation is cutaneous; however, it can manifest in various organ systems and is associated with a high degree of morbidity and mortality. Diagnosis is challenging, and there are no validated diagnostic or classification criteria. Most cases should be confirmed with tissue biopsy when possible given the severity of disease and the extent of immunosuppression required to treat this condition. We report the case of a 54-year-old white woman with long-standing, uncontrolled, and seropositive rheumatoid arthritis with a history of elevated anticardiolipin IgG and IgM antibodies who presented with acute stenosis of her left femoral artery which ultimately required a left above-the-knee amputation. Histopathology revealed findings consistent with vasculitis and thrombosis, and subsequent imaging revealed multifocal arterial and venous thromboses. She was diagnosed with rheumatoid vasculitis and antiphospholipid antibody syndrome, and was treated with high-dose glucocorticoids, cyclophosphamide, and warfarin. Rheumatoid vasculitis is a rare but devastating complication of rheumatoid arthritis, and vigilance for this condition must be maintained, especially in patients with long-standing, seropositive disease.

A Rare Case of Superior Vena Cava Syndrome in a Patient With Rheumatoid Arthritis and IgA Nephropathy

“…Although most cases of RV cause small-vessel stenosis via reactive intimal tissue, cases of mesenteric vasculitis as well as hepatic arteritis have been reported [ 8 ]. A case published in 2021 documented a patient with RV and antiphospholipid antibody syndrome presenting with inflammatory stenosis (confirmed with artery biopsy) of the femoral artery and widespread vasculitis of the deep muscular arteries and veins [ 9 ]. There have been only a handful of cases of SVCS in patients with RA.…”