An archival case of clinically significant infection in a surgical patient by enterotoxigenic Bacteroides fragilis: PCR amplification of the metalloprotease enterotoxin gene from non-viable lyophilizates

Belkum, Alex van; Leszczyński, P; Vogel, Mika W.; Verbrugh, Henri A.; Meisel-Mikołajczyk, F

doi:10.1111/j.1469-0691.1999.tb00118.x

Clinical Microbiology and Infection

1999

DOI: 10.1111/j.1469-0691.1999.tb00118.x

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An archival case of clinically significant infection in a surgical patient by enterotoxigenic Bacteroides fragilis: PCR amplification of the metalloprotease enterotoxin gene from non-viable lyophilizates

Alex van Belkum

P Leszczyński

Mika W. Vogel

et al.

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Cited by 2 publications

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Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence

Blanc¹,

Petignat²,

Moreillon³

et al. 1999

Clinical Infectious Diseases

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We describe the unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus (MRSA) clone in hospitals in western Switzerland, where the incidence of MRSA is usually low. During a 2-year period, this clone had been responsible for several outbreaks and had been isolated from >156 persons in 21 institutions. Molecular typing by pulsed-field gel electrophoresis (PFGE) demonstrated that all of these isolates belonged to the same clone. In 1 of the outbreaks, involving 30 cases, the clone was responsible for at least 17 secondary cases. In contrast, during the period of the latter outbreak, 9 other patients harboring different MRSA strains, as assessed by PFGE, were hospitalized in the same wards, but no secondary cases occurred. These observations suggest that this clone, compared with other MRSA strains, had some intrinsic factor(s) that contributed to its ability to disseminate and could thus be considered epidemic.

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Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence

Blanc¹,

Petignat²,

Moreillon³

et al. 1999

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

Methicillin-ResistantStaphylococcus aureus:Phylogenetic Relatedness Between European Epidemic Clones and Swiss Sporadic Strains

Blanc

Bañuls²,

Hauser³

et al. 2000

Microbial Drug Resistance

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We have compared the phylogenetic diversity of methicillin-resistant Staphylococcus aureus (MRSA) strains from Switzerland and their phylogenetic relationships with European epidemic clones, using multiprimer random amplification polymorphic DNA (RAPD). Strains included 24 European epidemic clones (59 strains), 66 sporadic strains isolated in Switzerland in 1996-1997, and 15 reference strains of five other Staphylococcus species. Similarity and clustering analysis with the Jaccard's coefficient showed that the maximum genetic distance between MRSA strains was 0.43, whereas the minimum genetic distance between the six Staphylococcus species was 0.97, indicating that the method permits phylogenetic hierarchization. The 24 MRSA clones reported to be epidemic in European countries during the 1990s were distributed into seven different genetic clusters with a maximum distance of 0.29 among them. This clustering pattern was confirmed by the analysis of a subset of MRSA strains by multilocus enzyme electrophoresis at 12 loci. Most of the sporadic Swiss strains were distributed into these seven different genetic clusters, together with the epidemic MRSA clones. This suggests that there is no phylogenetic cluster specific to epidemic clones of MRSA.

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An archival case of clinically significant infection in a surgical patient by enterotoxigenic Bacteroides fragilis: PCR amplification of the metalloprotease enterotoxin gene from non-viable lyophilizates

Cited by 2 publications

References 12 publications

Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence

Unusual Spread of a Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus Clone in a Geographic Area of Low Incidence

Methicillin-ResistantStaphylococcus aureus:Phylogenetic Relatedness Between European Epidemic Clones and Swiss Sporadic Strains

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