An Aqueous Facile Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives by Reverse Zinc Oxide Micelles as Nanoreactor

Abstract

A green synthetic protocol has been developed for the efficient preparation of 2,3-dihydroquinazolin−4(1H)-one derivatives with excellent yield in aqueous media. Reverse zinc oxide micelles catalyzed the reactions efficiently and selectively as the hallow nanoreactor. Moreover, the catalyst was reusable without significant loss of catalytic efficiency. The notable advantages of the procedure are high yields and mild reaction conditions, simple operation, nonchromatographic purification, environmentally friendly and good versatile substrates.

Sulfonated magnetic spirulina nanobiomaterial as a novel and environmentally friendly catalyst for the synthesis of dihydroquinazolin-4(1H)-ones in aqueous medium

“…Furthermore, these nanocatalysts boast crucial characteristics like high activity, stability, reusability, and environmentally friendly properties, making them significant in green chemistry 12 – 14 Dihydroquinazolin-4(1H)-one derivative is a fused heterocyclic compound with various applications in the pharmaceutical industry 15 , 16 . These compounds exhibit diverse biological activities, anticancer 17 , anticonvulsant 18 anti-inflammatory 19 , and antimalaria properties 20 . Due to their physiological significance and pharmaceutical potential, developing novel N-heterocyclic molecules is crucial in drug discovery and development.…”

Aluminium-based ionic liquid grafted on biochar as a heterogeneous catalyst for the selective synthesis of tetrazole and 2,3-dihydroquinazolin 4(1H)-one derivatives

“…48 Aqueous Facile Synthesis of 2,3-Dihydroquinazolin-4(1 H )-One Derivatives by Reverse Zinc Oxide was reported by Jie Mou and the other work in 2020 (homogenous catalyst, 90 °C, 5 h). 49 However, most of these protocols have limitations, such as excess oxidant, complicated reactions, harsh reaction conditions (up to 100 °C), tedious work-ups, non-renewable and toxic solvents, non-reusable catalyst, low yields and long reaction times. All of these approaches reveal that the catalytic formation of these compounds is still challenging and that the area demands to be developed further.…”

Caffeinium Hydrogen Sulphate Catalysed Green Synthesis of 2,3- Dihydroquinazolin-4(1H)-ones and Their Drug-likeness Studies as Antibacterial Agents

“…Among these, the cyclocondensation of anthranilamide with aryl aldehydes is the most effective and popular method for producing 2,3-dihydroquinazolin-4(1H)-ones. For this purpose various catalysts such as strong Bronsted acids, Lewis acids, metal triflates, ammonium salts [12], IL@MNP [13], tribromide ion supported on boehmite nanoparticles [14], B(C6F5)3 [15], nano-ZrO2-Al2O3 [16], urea/zinc chloride [17], Gr@SO3H [18], Fe3O4@PEG-diaza crown ether@Ni [19], Fe3O4@PEG-Ni [20], ZnO nanomicelle [21], SBA-15@n-Pr-THAM-ZrO [22] and MCM-41-SPM-DMG-Cu(II) [23] have been utilized. Many of these systems have several drawbacks, including poor product yields, long reaction times, difficult reaction conditions, expensive catalysts and hazardous solvents.…”