Pandya proposed the first steady-state rate-based model for the chemical absorption process in a packed column using the aqueous CO 2 −MEA system. Later several modeling studies are also reported based on Pandya's approach but limited to low pressure (≈1 bar) and low CO 2 loadings (<0.5 mol/mol). Recently, the interest in processing CO 2 -rich natural gas at high-pressure conditions has been increased. Therefore, in this study, the Pandya model is modified to simulate the packed absorption column using an aqueous CO 2 −MEA system for the high-pressure and high-CO 2 loading range. The sequential chemical reactions, along with the respective mass transfer resistances that occur at low (<0.5 mol/mol) and high (>0.5 mol/mol) CO 2 loadings, are added. This is achieved by theoretically segmenting the packed column into two sections. This strategy simplifies the computation of subsequent fast and slow reaction regimes that occur over a high-CO 2 loading range. The gas−liquid nonideal behavior is described using the Peng−Robinson (EOS) and Kent Eisenberg models. The developed model is effectively validated using the experimental data at low-(≈1.03 bar) and high-(50 bar) pressure conditions over a wide CO 2 loading range (≈0−1.0 mol/mol). In a parity plot between measured and simulated CO 2 concentration, R 2 is found to be 0.99 and 0.97, respectively, for the low-(≈1.03 bar) and high-(50 bar) pressure systems. This indicates that the proposed model can accurately predict the critical design parameters at the high-pressure and high-CO 2 loading conditions, with minimum computational intricacy.