An approach to the synthesis of heterocyclic analogs of steroids of the 8-azaestrane series

Ab + D → Abd → Abcd

“…The isoquinoline derivative 207 (Scheme 4-23, R = H or CH 3 0) reacted with /?-diketones in refluxing ethanol to give the 8-aza-12-ketosteroids 208 (R = CH 3 0, R' = H 2 [158]; R = CH 3 0, R' = 0 [159]) and 209 (R = CH 3 0, R' = H 2 , Z = NH [158]; R = C H , A R' = 0 , Z = C(CH 3 ) 2 [158]; R = H, R' = 0 , Z-C(CH 3 ) 2 [159]). …”