Intermediate vector bosons should be observable in the heavy-quark final states of high-energy p~collisions. Largetransverse-momentum like-sign dileptons would then provide a good W' signature. If the mass mixing between neutral B mesons is large, as usually predicted, the associated production of b quarks would give the most important background. In this case also, the Z 0 should be observable in the same channel. The cross sections for these processes are estimated. The W " signal turns out to be significantly large, especially in the forward-backward asymmetry between positive and negative dileptons.