An approach to the genus <i>Tanacetum</i> L. (Compositae): Phytochemical and pharmacological review

Abad, María J. F.; Bermejo, Paulina; Villar, A.

doi:10.1002/ptr.2650090202

Cited by 64 publications

(43 citation statements)

References 82 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tansy is a commonly grown domestic remedy that is reported to be useful in treating a variety of medical problems, such as kidney weakness, stomach problems, fever, hysteria [6]. Despite the widespread use of Tansy, little is known regarding the active component(s) responsible for its therapeutic effects.…”

Section: Discussionmentioning

confidence: 99%

“…Tansy is a perennial native to Europe and Asia; however, it was introduced to the United States for medicinal and horticultural purposes and now grows wild throughout many states. Extracts from this plant have been used extensively in folk medicine for treating rheumatism, ulcers, fever, and digestive disorders, and compounds isolated from this plant have also been reported to exhibit antibacterial and antihelminthic activity [6,7]. Indeed, a number of biologically active low M r compounds, such as flavonoids and terpenoids, isolated from this species have been shown to be physiologically active [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.

Xie

Schepetkin

Quinn

2007

International Immunopharmacology

View full text Add to dashboard Cite

Tanacetum vulgare L. (Tansy) has been extensively used in folk medicine for treatment of a variety of medical disorders. In the present study, we isolated and purified four acidic polysaccharide fractions (designated T-I to T-IV) from Tansy florets by the sequential use of hot-water extraction, ethanol precipitation, ultra-filtration, anion-exchange, and size-exclusion chromatography. The average M r of fractions T-I through T-IV was estimated to be 326, 151, 64 and 9 kDa, respectively, as determined by high performance size-exclusion chromatography analysis. Sugar composition analysis revealed that Tansy polysaccharides consisted primarily of galacturonic acid, galactose, arabinose, and rhamnose. Fractions T-II through T-IV contained an arabinogalactan type II structure, as determined by reaction with Yariv reagent. High M r fractions T-I and T-II exhibited potent macrophage/monocyte-activating activity, enhancing production of reactive oxygen species (ROS), nitric oxide (NO), and tumor necrosis factor α (TNF-α) by J774.A1 murine macrophages, and activating nuclear factor κB (NF-κB) in THP-1 human monocytes. In addition, Tansy polysaccharides stimulated human neutrophil function by greatly enhancing neutrophil myeloperoxidase (MPO) release. Furthermore, the low M r fraction T-IV had potent complementfixing activity, which may also contribute to the anti-inflammatory and would-healing properties of Tansy extracts. Taken together, our results provide a molecular basis to explain at least part of the beneficial therapeutic effects of Tansy extracts, and support the concept of using Tansy polysaccharides as an immunotherapeutic adjuvant.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.

Xie

Schepetkin

Quinn

2007

International Immunopharmacology

View full text Add to dashboard Cite

show abstract

“…The structure of the isolated compound was identified by chromatography-mass spectrometry (Micromass Quattro LC); nuclear magnetic resonance (NMR; Gemini 2000 BB; Varian), 1 H NMR (300 MHz), and 13 C NMR (75.5 MHz) analyses in CDCl 3 ; infrared analysis (Bomem-MV 100; Hartmann & Braun-Michelson); and UV analysis (CARY 1E UV-Vis; Varian). A structure corresponding to a sesquiterpene lactone, 4␣,5␤-epoxy-germacra-1-(10),11(13)-dien-12,6␣-olide (parthenolide), was identified (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Plants of the genus Tanacetum are reputed to have excellent medicinal value. The large number of sesquiterpenoids and sesquiterpene lactones that are typical constituents of these plants might be partly or wholly responsible for these effects (1).…”

mentioning

confidence: 99%

Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium

Tiuman

Ueda-Nakamura

Cortez³

et al. 2005

Antimicrob Agents Chemother

182

116

View full text Add to dashboard Cite

The in vitro activity of parthenolide against Leishmania amazonensis was investigated. Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract of aerial parts of Tanacetum parthenium. This isolated compound was identified through spectral analyses by UV, infrared, 1 H and 13 C nuclear magnetic resonance imaging, DEPT (distortionless enhancement by polarization transfer), COSY (correlated spectroscopy), HMQC (heteronuclear multiple-quantum coherence), and electron spray ionization-mass spectrometry. Parthenolide showed significant activity against the promastigote form of L. amazonensis, with 50% inhibition of cell growth at a concentration of 0.37 g/ml. For the intracellular amastigote form, parthenolide reduced by 50% the survival index of parasites in macrophages when it was used at 0.81 g/ml. The purified compound showed no cytotoxic effects against J774G8 macrophages in culture and did not cause lysis in sheep blood when it was used at higher concentrations that inhibited promastigote forms. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis with gelatin as the substrate showed that the enzymatic activity of the enzyme cysteine protease increased following treatment of the promastigotes with the isolated compound. This finding was correlated with marked morphological changes induced by parthenolide, such as the appearance of structures similar to large lysosomes and intense exocytic activity in the region of the flagellar pocket, as seen by electron microscopy. These results provide new perspectives on the development of novel drugs with leishmanicidal activities obtained from natural products.

show abstract

“…O forte odor característico da espécie é decorrente das altas concentrações de terpenos voláteis, constituintes do óleo essencial, encontrado especialmente em folhas e inflorescências (Berry, 1984;Abad et al, 1995;Figueiredo, 1998). Produz cerca de trinta lactonas sesquiterpênicas, sendo o partenolídeo identificado em 1982 no extrato da parte aérea, a lactona sesquiterpênica predominante nessas plantas (Bohlmann e Zdero, 1982;Dolman et al, 1992;Kéry et al, 1993).…”

Section: Introductionunclassified

Crescimento, teor de partenolídeo e de prolina em plantas de <em>tanacetum parthenium</em> (l.) Schultz-Bip crescidas em substrato com diferentes teores de umidade

Carvalho¹,

Casali

Souza³

et al. 2005

Acta Sci. Agron.

View full text Add to dashboard Cite

RESUMO.Com o objetivo de determinar o efeito do teor de umidade do substrato sobre o teor de partenolídeo na parte aérea das plantas, cultivou-se a artemísia [Tanacetum parthenium (L.) Schultz Bip.] em vasos de 5 L com substrato mantido a 100%, 90%, 70% ou 50% da capacidade de campo. Nos níveis de maior disponibilidade hídrica no substrato, verificou-se maior altura, número de folhas, área foliar total e teor de partenolídeo. No menor nível de disponibilidade de água no solo verificou-se redução de 16% na altura das plantas, de 13% no número de folhas, de 14% na área foliar total e de 28% no teor de partenolídeo, além de aumento no teor de prolina. Conclui-se que os maiores teores de umidade no substrato são mais indicados à produção de plantas com maior teor de partenolídeo.Palavras-chave: planta medicinal, deficiência hídrica, princípio ativo.ABSTRACT. Growth, parthenolide and proline contents in Tanacetum parthenium (L. ) Schultz Bip. in substratum of different humidity contents. Aiming at determining the effect of soil's water levels on the parthenolide contents of plants aerial parts, this experiment used feverfew [Tanacetum parthenium (L. ) Schultz Bip. ], grown in 5-L vases, with substratum kept at 100%, 90%, 70% and 50% field capacity. In the substratum highest water availability levels, plants showed larger height, more leaves, higher total leaf area and higher parthenolide content. In the lowest water availability level, the following decreases were verified: 16% in plants height, 13% in number of leaves, 14% in leaf area and 28% in parthenolide content, and an increase in the proline content. This suggests that higher water levels in soil are more appropriate for producing plants with larger parthenolide content.

show abstract

An approach to the genus Tanacetum L. (Compositae): Phytochemical and pharmacological review

Cited by 64 publications

References 82 publications

Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.

Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.

Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium

Crescimento, teor de partenolídeo e de prolina em plantas de <em>tanacetum parthenium</em> (l.) Schultz-Bip crescidas em substrato com diferentes teores de umidade

Contact Info

Product

Resources

About