An approach to the asymmetric synthesis of 18F-labeled analog of l-threo-3,4-dihydroxyphenylserine (6-l-threo-[18F]FDOPS) — a new radiotracer for visualization of norepinephrine transporters by positron emission tomography

This review article critically discusses examples of asymmetric synthesis of tailor-made α-amino acids via homologation of Ni(II) complexes of glycine and alanine Schiff bases, reported in the literature from 2013 through the end of 2016. Where it is possible, reaction mechanism and origin of the stereochemical outcome is discussed in detail. Special attention is given to various aspects of practicality and scalability of the reported methods. Among the most noticeable developments in this area are novel designs of axially chiral ligands, application of electro- and mechano-chemical (ball-milling) conditions, and development of dynamic kinetic resolution procedures.

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Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes

Wang

Song

Wang

et al. 2017

Amino Acids

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New fluorine-18 labeled benzaldehydes as precursors in the synthesis of radiopharmaceuticals for positron emission tomography

et al. 2016

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A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography

Savel’yeva,

Gugkaeva,

Nelyubina

et al. 2024

Mendeleev Communications

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An approach to the asymmetric synthesis of 18F-labeled analog of l-threo-3,4-dihydroxyphenylserine (6-l-threo-[18F]FDOPS) — a new radiotracer for visualization of norepinephrine transporters by positron emission tomography

Cited by 4 publications

References 27 publications

Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes

Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes

New fluorine-18 labeled benzaldehydes as precursors in the synthesis of radiopharmaceuticals for positron emission tomography

A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography

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