An Approach to Reveal the Possible Underlying Mechanisms Inherent to Oecophylla smaragdina as a Biocontrol Agent

Pharmacological potential of ants and their symbionts – a review

“…However, the GC-MS analysis of O. smaragdina venom reported the presence of bioactive neurotoxin, namely 2,4-bis(1,1-dimethylethyl) phenol (or 2,4-DTBP) (Das et al, 2019). Besides its neurotoxic activity, 2,4-DTBP shows anti-malarial activity by inhibiting nAChRs of muscles in humans (Gisselmann et al, 2018;Das et al, 2019). This compound is also secreted by samsum ants (P. senaarensis) along with trimethyl pyrazine which is known for its antiinflammatory, antioxidant, and anti-fungal properties, as well as inhibition of bacterial biofilm formation (Osada & Shibamoto, 2006;Dkhil et al, 2010;Rangel-Sánchez et al, 2014;Arruda Macêdo et al, 2015;Phillips et al, 2015).…”

“…For example, the gas chromatography‐mass spectrometry (GC‐MS) analysis of ethanolic extract of O. smaragdina has revealed the presence of dodecanoic acid that is known for its antioxidant, anti‐bacterial, anti‐viral, and hypocholesterolemic activities along with fumaric acid, 2‐dimethylaminoethyl heptyl ester, that is used in the treatment of psoriasis (Balak, 2015; Natarajan et al, 2019). However, the GC‐MS analysis of O. smaragdina venom reported the presence of bioactive neurotoxin, namely 2,4‐bis(1,1‐dimethylethyl) phenol (or 2,4‐DTBP) (Das et al, 2019). Besides its neurotoxic activity, 2,4‐DTBP shows anti‐malarial activity by inhibiting nAChRs of muscles in humans (Gisselmann et al, 2018; Das et al, 2019).…”

“…However, the GC‐MS analysis of O. smaragdina venom reported the presence of bioactive neurotoxin, namely 2,4‐bis(1,1‐dimethylethyl) phenol (or 2,4‐DTBP) (Das et al, 2019). Besides its neurotoxic activity, 2,4‐DTBP shows anti‐malarial activity by inhibiting nAChRs of muscles in humans (Gisselmann et al, 2018; Das et al, 2019). This compound is also secreted by samsum ants ( P .…”