An approach to represent a combined exposure to air pollution

Szyszkowicz, Mieczysław

doi:10.13075/ijomeh.1896.00380

Cited by 9 publications

(5 citation statements)

References 18 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various methodologies have been advanced to develop multipollutant exposure indexes/metrics to assess multipollutant health effects. For example, Stieb et al [10] and Szyszkowicz [11] developed air quality health indexes based on combinations of air pollutants’ short-term health associations. Coull et al [12] applied Bayesian kernel machine regression that included a hierarchical variable selection function to estimate complex multipollutant health effects and identify important mixture components.…”

Section: Introductionmentioning

confidence: 99%

Pediatric emergency department visits and ambient Air pollution in the U.S. State of Georgia: a case-crossover study

et al. 2016

View full text Add to dashboard Cite

BackgroundEstimating the health effects of ambient air pollutant mixtures is necessary to understand the risk of real-life air pollution exposures.MethodsPediatric Emergency Department (ED) visit records for asthma or wheeze (n = 148,256), bronchitis (n = 84,597), pneumonia (n = 90,063), otitis media (n = 422,268) and upper respiratory tract infection (URI) (n = 744,942) were obtained from Georgia hospitals during 2002–2008. Spatially-contiguous daily concentrations of 11 ambient air pollutants were estimated from CMAQ model simulations that were fused with ground-based measurements. Using a case-crossover study design, odds ratios for 3-day moving average air pollutant concentrations were estimated using conditional logistic regression, matching on ZIP code, day-of-week, month, and year.ResultsIn multipollutant models, the association of highest magnitude observed for the asthma/wheeze outcome was with “oxidant gases” (O3, NO2, and SO2); the joint effect estimate for an IQR increase of this mixture was OR: 1.068 (95% CI: 1.040, 1.097). The group of “secondary pollutants” (O3 and the PM2.5 components SO4 2−, NO3−, and NH4+) was strongly associated with bronchitis (OR: 1.090, 95% CI: 1.050, 1.132), pneumonia (OR: 1.085, 95% CI: 1.047, 1.125), and otitis media (OR: 1.059, 95% CI: 1.042, 1.077). ED visits for URI were strongly associated with “oxidant gases,” “secondary pollutants,” and the “criteria pollutants” (O3, NO2, CO, SO2, and PM2.5).ConclusionsShort-term exposures to air pollution mixtures were associated with ED visits for several different pediatric respiratory diseases.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-016-0196-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Pediatric emergency department visits and ambient Air pollution in the U.S. State of Georgia: a case-crossover study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Inhaled SO 2 can be easily hydrated to produce sulfurous acid in the respiratory tract, which subsequently dissociates to form its derivatives‐bisulfite and sulfite (1:3 M/M, in neutral fluid), which can be absorbed into blood or other body fluid. Previous studies reported that SO 2 exposure not only induced many respiratory responses, but also linked with many neurological disorders such as migraine headaches and stroke . In addition, SO 2 inhalation can impair learning and memory, and induce differential synaptic injury participated in synaptic transmission and cognitive impairment .…”

Section: Introductionmentioning

confidence: 99%

Co‐exposure to fluoride and sulfur dioxide on histological alteration and DNA damage in rat brain

Wang

Liang

et al. 2017

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Fluoride (F) and sulfur dioxide (SO ) are the two common environmental contaminants that are associated with neurotoxicity. The present study was conducted to explore individual and combined exposure effects of F and SO on histological alteration and DNA damage in rat brain. For this, male Wistar albino rats were exposed to sodium fluoride (100 mg/L NaF) and sulfur dioxide (39.3 mg/m ) individually and in combination for 8 weeks. Histological alteration in brain is evaluated by hematoxylin-eosin staining, showed shrunken neurons, darkly stained small nucleus and decreased cell numbers in F and SO exposed groups. The effect of F and SO on DNA damage was assessed by comet assay. The results showed an increase in ratio of tailing and tail length in F or/and SO administered rats. In addition, the proportion of grade II and III were also increased in individual and combined exposed groups. Compared with the individual exposure, the proportion the grade III was significantly high in combined exposure, suggesting a synergistic effect of F and SO . These results indicate that the brain was more susceptible to the toxic effects of F and SO . And combined exposure to these pollutants can lead more pronounced toxic effects on brain.

show abstract

“…Predominantly, this is due to the strong correlations between NO 2 and other combustion-derived air pollutants, especially PM. Many studies [ 7 , 14 , 26 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 ] underline a positive correlation between NO 2 and PM 2.5 . In some studies, NO 2 has been proposed as a surrogate for PM [ 115 , 116 ]; in others, the confounding effects of PM 2.5 are also underlined [ 88 , 117 ].…”

Section: Considerations and Discussionmentioning

confidence: 99%

Synergistic or Antagonistic Health Effects of Long- and Short-Term Exposure to Ambient NO2 and PM2.5: A Review

Mainka

Żak

2022

IJERPH

View full text Add to dashboard Cite

Studies on adverse health effects associated with air pollution mostly focus on individual pollutants. However, the air is a complex medium, and thus epidemiological studies face many challenges and limitations in the multipollutant approach. NO2 and PM2.5 have been selected as both originating from combustion processes and are considered to be the main pollutants associated with traffic; moreover, both elicit oxidative stress responses. An answer to the question of whether synergistic or antagonistic health effects of combined pollutants are demonstrated by pollutants monitored in ambient air is not explicit. Among the analyzed studies, only a few revealed statistical significance. Exposure to a single pollutant (PM2.5 or NO2) was mostly associated with a small increase in non-accidental mortality (HR:1.01–1.03). PM2.5 increase of <10 µg/m3 adjusted for NO2 as well as NO2 adjusted for PM2.5 resulted in a slightly lower health risk than a single pollutant. In the case of cardiovascular heart disease, mortality evoked by exposure to PM2.5 or NO2 adjusted for NO2 and PM2.5, respectively, revealed an antagonistic effect on health risk compared to the single pollutant. Both short- and long-term exposure to PM2.5 or NO2 adjusted for NO2 and PM2.5, respectively, revealed a synergistic effect appearing as higher mortality from respiratory diseases.

show abstract

An approach to represent a combined exposure to air pollution

Cited by 9 publications

References 18 publications

Pediatric emergency department visits and ambient Air pollution in the U.S. State of Georgia: a case-crossover study

Pediatric emergency department visits and ambient Air pollution in the U.S. State of Georgia: a case-crossover study

Co‐exposure to fluoride and sulfur dioxide on histological alteration and DNA damage in rat brain

Synergistic or Antagonistic Health Effects of Long- and Short-Term Exposure to Ambient NO2 and PM2.5: A Review

Contact Info

Product

Resources

About